Advertisement

Clinical Investigation of Lithium Therapy in Acute Leukemia

  • Dominique J. Charron
  • Thierry Schmitt
  • Laurent Degos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Abstract

It has been known for a long time that patients receiving lithium carbonate (Li2CO3 for manic-depressive psychosis develop a significant polymorphonuclear leukocytosis (Bille and Plum, 1955; Shopsin et al., 1971). Moreover, in vitro studies have demonstrated a stimulatory effect of Li2CO3 on granulopoiesis (Tisman et al., 1973; Harker et al., 1975) and have suggested that Li2CO3 acts either by increasing colony stimulating factor (CSF) production by mononuclear cells (Harker et al., 1977) or potentiating the action of CSF (Morley and Galbraith, 1978). The exact mechanism has yet to be clarified by extended in vivo and in vitro studies, although the present data support the evidence for a multilevel action.

Keywords

Acute Lymphoblastic Leukemia Aplastic Anemia Acute Leukemia Disseminate Intravascular Coagulation Hairy Cell Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barrett, A.J., Longhurst, P.A., Newton, K.A., and Humble, J.B., 1976, Treatment of a patient with aplastic anemia with lithium carbonate, Exp. Hematol. 4:42.Google Scholar
  2. Barrett, A.J., Griscelli, C, Buriot, D., and Faille, A., 1977, Lithium therapy in congenital neutropenia, Lancet 2:1357.PubMedCrossRefGoogle Scholar
  3. Bille, M., and Plum, CM., 1955, Komplikationer ved lithium-behandling, Vgeskrift for Laeger 117:293.Google Scholar
  4. Binet, J.L., Leporrier, M., Dighiero, G., Charron, D., D’Athis, Ph., Vaugier, G., Beral, H.M., Natali, J.C., Raphael, M., Nizet, B., and Follezou, J.Y., 1977, A clinical staging system for CLL prognostic significance, Cancer 40:855.PubMedCrossRefGoogle Scholar
  5. Charron, D., 1977, Classification anatomo-clinique de la leucemie lymphoide chronique. Signification pronostique, Thesis Medicine, Paris University.Google Scholar
  6. Charron, D., Barrett, A.J., Faille, A., Alby, N., Schmitt, T., and Degos, L., 1977, Lithium in acute myeloid leukemia, Lancet 1:1307.PubMedCrossRefGoogle Scholar
  7. Dorus, E., Pandey, G.N., and Davis, J.M., 1975, Genetic determinant of lithium ion distribution, Arch. Gen. Psychiatry 32:1097.PubMedCrossRefGoogle Scholar
  8. Greco, F.A. and Brereton, E., 1977, Effect of lithium carbonate on the neutropenia caused by chemotherapy, a clinical trial, Oncology 34:153.PubMedCrossRefGoogle Scholar
  9. Gupta, R.C., Robinson, W.A., and Kurnick, J.E., 1976, Felty’s Syndrome — Effect of lithium on granulopoiesis, Am. Jour. Med. 61:29.CrossRefGoogle Scholar
  10. Hamilton, ML, 1959, The assessment of anxiety states by rating, Brit. J. Med. Psychol. 32:50CrossRefGoogle Scholar
  11. Harker, G.W., Rothstein, G., Clarkson, D.W., and Athens, J.W., 1975, Stimulation of neutrophil production by lithium, Clin. Res. 23:103A.Google Scholar
  12. Harker, G.W., Rothstein, G., Clarkson, D., Athens, J.W. and MacFarlane, J.L., 1977, Enhancement of colony-stimulating activity production by lithium, Blood 49:263.PubMedGoogle Scholar
  13. Jacquillat, D., Weil, M., Auclerc, M.F., Maral, R., Izrael, V., and Bernard, J., 1978, Clinical activity of a new anthracycline derivative in malignant diseases, Proc. Am. Assoc. Cancer Res. 19:362.Google Scholar
  14. Lee, R.V., Jampol, L.M., and Brown, W.V., 1971, Nephrogenic diabetes insipidus and lithium intoxication — complications of lithium carbonate therapy, New Eng. J. Med. 284:93.PubMedCrossRefGoogle Scholar
  15. Marie, J.P., Degos, L., and Flandrin, G., 1977, Hairy cell leukemia and tuberculosis, New Eng. J. Med. 297:1354.Google Scholar
  16. Morley, D.C. and Galbraith, P.R., 1978, Effect of lithium on granulopoiesis in culture, Canad. Med. Assn. J. 118:288.Google Scholar
  17. Schou, M., 1968, Litnium in psychiatric therapy and prophylaxis, J. Psychiat. Res. 6:67.PubMedCrossRefGoogle Scholar
  18. Schou, M., Amidsen, A., and Trap-Jensen, J., 1968, Lithium poisoning, Am. J. Psychiatry 125:520.PubMedGoogle Scholar
  19. Shenkman, L., Borkowsky, W., Hulzman, R.S., and Shopsin, B., 1978, Enhancement of lymphocyte and macrophage function in vitro by lithium chloride, Clin. Immunol. Immunopath. 10:187.CrossRefGoogle Scholar
  20. Shopsin, B., Friedman, R., and Gershon, S., 1971, Lithium and leukocytosis, Clin. Pharm. and Therapeutics 12:923.Google Scholar
  21. Tisman, G., Herbert, V., and Rosenblatt, S., 1973, Evidence that lithium induces human granulocyte proliferation: Elevated serum vitamin B12 binding capacity in vivo and granulocyte colony proliferation in vitro, Brit. J. Haem. 24:267.CrossRefGoogle Scholar
  22. Tisman, G., 1974, Lithium carbonate protection against drug induced leukopenia in lymphosarcoma patients, IRCS 2:1509.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Dominique J. Charron
    • 1
  • Thierry Schmitt
    • 1
  • Laurent Degos
    • 1
  1. 1.Institut de Recherche sur les Maladies du SangHopital Saint-LouisParisFrance

Personalised recommendations