Nuclear Terminal Deoxynucleotidyl Transferase (Tdt) in Leukemic Infiltrates of Testicular Tissue

  • G. Janossy
  • J. A. Thomas
  • O. B. Eden
  • F. J. Bollum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 145)


Carefully monitored chemotherapy regimes and prophylactic control of meningeal disease1,2 have contributed to prolonged hematological remissions in childhood acute lymphoblastic leukemia (ALL). With this lengthened remission duration leukemic infiltration of the testis has become an increasingly recognised complication in boys especially after cessation of maintenance therapy3. Many centers have therefore instituted the policy of routine testicular biopsy before cessation of therapy in order to detect residual disease in this site4,5.


Acute Lymphoblastic Leukemia Testicular Tissue Leukemic Blast Testicular Biopsy Childhood Acute Lymphoblastic Leukemia 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. Janossy
    • 1
  • J. A. Thomas
    • 1
  • O. B. Eden
    • 2
  • F. J. Bollum
    • 3
  1. 1.Department of ImmunologyRoyal Free HospitalLondonUK
  2. 2.Bristol Children’s Hospital & S.W. Regional Blood Transfusion CentreSouthmead BristolUK
  3. 3.Uniformed Services University of the Health SciencesBethesdaUSA

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