Abstract
The deliberate evolution of conceptual conjectures has often acted as a spur and a guide for the experimental exploration of reality. That is the underlying theme of this paper. David Keilin’s concept of the respiratory chain is an excellent example. For strategic reasons, I propose to confine my commentary mainly to the part of the mitochondrial respiratory chain from succinate to oxygen, where our present knowledge of stoichiometry and possible mechanism provides a comparatively well-defined basis for constructive discussion and for the planning of further experimental exploration.
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Mitchell, P. (1987). Respiratory Chain Systems in Theory and Practice. In: Kim, C.H., Tedeschi, H., Diwan, J.J., Salerno, J.C. (eds) Advances in Membrane Biochemistry and Bioenergetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8640-7_4
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