Purine Salvage Enzymes in Lymphocytes and Granulocytes from Patients with Small-Cell Carcinoma of the Lung
An impaired immune function is frequently seen in patients with malignant diseases. This suggests that the cell-mediated immune response plays a role in the defence against the development of such diseases. Disordered immune function has been associated with specific defects in some purine enzymes: adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5′-nucleotidase (5′N) (1). The association between these enzyme deficiencies and the immune disorder has been explained to be due to an accumulation of purine nucleosides and nucleotides, which exert toxic effects especially on lymphoid cells. Deficiencies in other purine enzymes such as hypoxanthine phosphoribosyltransferase (HGPRT) and adenine phosphoribosyltransferase (APRT) have not been associated with immunological abnormalities.
KeywordsAdenosine Deaminase Purine Nucleoside Phosphorylase Adenosine Kinase Hypoxanthine Phosphoribosyltransferase Impaired Immune Function
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