Abstract
Purine metabolizing enzymes refer to a series of enzymes which synthesize, transform and catabolize purine compounds. The salvage of purines and purine nucleosides provides the cells with nucleotides in addition to those derived from the biosynthesis de novo; purine salvage may be the only or major pathway by which leukocytes synthesize their purine nucleotides.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Giblett, E. R., Anderson, J. E., Cohen, F., Pollara, B. and Meuwissen, H. J. (1972). Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Lancet, ii, 1067
Giblett, E. R., Ammann, A. J., Wara, D. W., Sandman, R. and Diamand, L. K. (1975). Nucleoside phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet, i, 1010
Carson, D. A. and Seegmiller J. E. (1976). Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. J. Clin. Invest., 57, 274
Bøyum, A. (1974). Separation of blood leukocytes, granulocytes and lymphocytes. Tissue Antigen., 4, 269
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951). Protein measurement with folin phenol reagent. J. Biol. Chem., 193, 256
Jensen, K. F. and Nygaard, P. (1975). Purine nucleoside phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and some properties. Eur. J. Biochem., 51, 253
Jochimsen, B., Nygaard, P. and Vestergaard, T. (1975). Location on the chromosome of Escherichia coli of genes governing purine metabolism. Mol. Gen. Genet., 143, 85
Uberti, J., Johnson, R. M., Talley, R. and Lightbody, J. J. (1976). Decreased lymphocyte adenosine deaminase activity in tumor patients. Cancer Res., 36, 2046
Zimmer, J., Khalifa, S. A. and Lightbody, J. J. (1975). Decreased lymphocyte adenosine deaminase activity in acute lymphocytic leukaemic children and their parents. Cancer Res., 35, 68
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 The Society for the Study of Inborn Errors of Metabolism
About this chapter
Cite this chapter
Mejer, J., Nygaard, P. (1979). Ageing and activities of purine metabolizing enzymes in leukocytes. In: Güttler, F., Seakins, J.W.T., Harkness, R.A. (eds) Inborn Errors of Immunity and Phagocytosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6197-8_12
Download citation
DOI: https://doi.org/10.1007/978-94-011-6197-8_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6199-2
Online ISBN: 978-94-011-6197-8
eBook Packages: Springer Book Archive