Abstract
It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule. Sometimes the assignment of receptors for drugs can be quite straightforward, as in the case of organophosphate insecticides. These agents are enzyme inhibitors, chemically reacting with serine residues in a number of esterase enzymes. The enzymes associated with the hydrolysis of acetylcholine are therefore receptors for organophosphates, and the pharmacological and toxicological effects of these agents can be explained, virtually entirely, by the interaction of the organophosphate with these enzymes.
The erratum of this chapter is available at http://dx.doi.org/10.1007/978-1-4684-7793-1_16
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sobell, H. M., and Jain, S. C.: The stereochemistry of actino- mycin binding to DNA. J. Mol. Biol. 68: 1 - 27, (1972).
Meadows, D. H., Roberts, G. K., and Jardetzky, O.: Nuclear magnetic resonance studies of the structure and binding sites of enzymes. VIII. Inhibitor binding to ribonuclease. J. Mol. Biol. 45: 491 - 511 (1969).
Brewer, C. F., Sternlicht, H., Marcus, D. M., and Grollman, A. P.: Interactions of saccharides with concanvalin A. Mechanism of binding of a-and 8-methyl D- glucopyranoside to concanavalin A as determined by 13C nuclear magnetic resonance. Biochem. 12: 4448 - 4457 (1973).
Ruhmann, A. G., and Berliner, D. L.: Effect of steroids on growth of mouse fibroblasts in vitor. Endocrinology 76: 916 - 927 (1956).
Berliner, D. L., and Ruhmann, A. G.: Comparison of the growth of fibroblasts under the influence of 11-beta hydroxy and 11keto corticosteroids. Endocrinology 78: 373 - 382 (1966).
Pratt, W. B., and Aronow, L.: The effect of glucocorticoids on protein and nucleic acid synthesis in mouse fibroblasts growing in vitro. J. Biol. Chem. 241: 5244 - 5250 (1966).
Nandi, S. J.: Endocrine control of mammary-gland development and function in the C3H/He Crgl mouse. J. Natn. Cancer Inst. 21: 1039 - 1063 (1958).
Leffert, H. L.: Growth control of differentiated fetal rat hepatoxytes in primary monolayer culture. VII. Hormonal control of DNA synthesis and its possible significance to the problem of liver regeneration. J. Cell Biol. 62: 792 - 801 (1974).
Thrash, C. R., Ho, T.-S., and Cunningham, D. C.: Structural features of steroids which initiate proliferation of density-inhibited 3T3 mouse fibroblasts. J. Biol. Chem. 249: 6099 - 6103 (1974).
Jiminez de Asua, L., Carr, B., Clingan, D., and Rudland, P.: Specific glucocorticoid inhibition of growth promoting effects of prostaglandin F2a on 3T3 cells. Nature 265: 450 - 452 (1977).
Gray, J. G., Pratt, W. B., and Aronow, L.: Effect of glucocorticoids on hexose uptake by mouse fibroblasts in vitro. Biochemistry 10: 277 - 284 (1971).
Wong, M. D., and Aronow, L.: Identification of a glucocorticoid-sensitive histone protein from mouse fibroblast nuclei Biochem. Biophys. Res Commun. 71: 265 - 271 (1976).
Hackney, J. F., Gross, S. R., Aronow, L., and Pratt, W. B.: Specific glucocorticoid-binding macromolecules from mouse fibroblasts grwoing in vitro. A possible steroid receptor for growth inhibition. Mol. Pharmacol. 6: 500 - 512 (1970).
Pratt, W. B. and Ishii, D. N.: Specific binding of glucocorticoids in vitro in the soluble fraction of mouse fibroblasts. Biochem. 11: 1401 - 1410 (1972).
Middlebrook, J. L., Wong, M. D., Ishii, D. N., and Aronow, L.: Subcellular distribution of glucocorticoid receptors in mouse fibroblasts. Biochemistry 14: 180 - 186 (1975).
Ishii, D. N., Pratt, W. B., and Aronow, L.: Steady-state level of the specific glucocorticoid binding component in mouse fibroblasts. Biochemistry 11: 3896 - 3904 (1972).
Bustin, M., and Cole, R. D.: Species and organ specificity in very lysine-rich histones. J. Biol. Chem. 243: 4500 - 4504 (1968).
Panyim, S., and Chalkley, G. R.: The heterogeneity of histones. I. A quantitative analysis of calf histones in very long polyacrilamide gels. Biochemistry 8: 3972 - 3979 (1969).
Varricchio, F.: Postnatal increase in histone Hla in the rat pancreas. Arch. Biochem. Biophys. 179: 715 - 717 (1977).
Cake, M. H., and Litwack, G.: The glucocorticoid receptor. In: Biochemical Actions of Hormones. Litwack, G. (ed.), Vol. III. New York: Academic Press, 1975.
Giannopoulos, G.: Ontogeny of glucocorticoid receptors in rat liver. J. Biol. Chem. 250: 5847 - 5851 (1975).
Cake, M. H., Ghisalberti,A. V., and Oliver, I. T.: Cytoplasmic binding of dexamethasone and induction of tyrosine amino-transferase in neonatal rat liver. Biochem. Biophys. Res. Commun. 54: 983 - 990 (1973).
Henning, S. J., Ballard, P.L., and Kretchmer, N.: A study of the cytoplasmic receptors for glucocorticoids in intestines of pre-and postweanling rats. J. Biol. Chem. 250: 2073 - 2079 (1975).
Henning, S. J., Helman, T. A., and Kretchmer, N.: Studies on normal and precocious appearance of jejunal sucrase in suckling rats. Biol. Neonate 26: 249 - 262 (1975).
Lippman, M. E., Wiggert, B. O., Chader, G. J., and Thompson, E. B.: Glucocorticoid receptors. Characteristics, specificity, and ontogenesis in the embryonic chick neural retina. J. Biol. Chem. 249: 5916 - 5917 (1974).
Roth, G. S.: Age-related changes in specific glucocorticoid binding by steroid-responsive tissues of rats. Endocrinology 94: 82 - 90 (1974).
Roth, G. S.: Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness. Fed. Proc. 34: 183 - 185 (1975).
Roth, G. S.: Reduced glucocorticoid responsiveness and receptor concentration in splenic leukocytes of senescent rats. Biochem. Biophys. Acta 399: 145 - 156 (1975).
Roth, G. S., and Livingston, J. N.: Reductions in glucocorticoid inhibition of glucose oxidation and presumptive glucocorticoid receptor content in rat adipocytes during aging. Endocrinology 99: 831 - 839 (1976).
Shain, S. A., Boesel, R. W., and Axelrod, L. R.: Aging in the rat prostate. Reduction in detectable ventral prostate androgen receptor content. Arch. Biochem. Biophys. 167: 247 - 263 (1975).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Science+Business Media New York
About this chapter
Cite this chapter
Aronow, L. (1978). Drug-Receptor Interactions. In: Roberts, J., Adelman, R.C., Cristofalo, V.J. (eds) Pharmacological Intervention in the Aging Process. Advances in Experimental Medicine and Biology, vol 97. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7793-1_3
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7793-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7795-5
Online ISBN: 978-1-4684-7793-1
eBook Packages: Springer Book Archive