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Role of Receptor Coupling to Phosphoinositide Metabolism in the Therapeutic Action of Lithium

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Molecular Mechanisms of Neuronal Responsiveness

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 221))

Abstract

Lithium is one of the most effective psychopharmacological treatments for affective illness and offers a potential avenue for furthering our understanding of the neurobiological components of this disorder. Among the most specific and potent actions of lithium is its ability to not only treat the acute episode of mania but also reduce the frequency and severity of recurrent episodes of mania and depression in bipolar patients and depression in unipolar patients (Bunney and Garland, 1984). Thus, the unique action of lithium appears to be its long-term ability to dampen pathological neurobiological oscillations in individuals vulnerable to profound cyclic affective disturbances.

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  1. Neuroscience Research Unit, Department of Psychiatry College of Medicine, University of Vermont, Burlington, Vermont, 05405, USA

    Robert H. Lenox

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  1. Robert H. Lenox
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  1. The University of Vermont College of Medicine, Burlington, Vermont, USA

    Yigal H. Ehrlich , Robert H. Lenox  & Elizabeth Kornecki ,  & 

  2. Bolling A.F. Base, U.S. Air Force Office of Scientific Research, Washington, D.C., USA

    William O. Berry

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© 1987 Plenum Press, New York

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Lenox, R.H. (1987). Role of Receptor Coupling to Phosphoinositide Metabolism in the Therapeutic Action of Lithium. In: Ehrlich, Y.H., Lenox, R.H., Kornecki, E., Berry, W.O. (eds) Molecular Mechanisms of Neuronal Responsiveness. Advances in Experimental Medicine and Biology, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7618-7_37

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  • DOI: https://doi.org/10.1007/978-1-4684-7618-7_37

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