Abstract
We performe TSH dry-spot screening as “Central CH-Screening for SH” since 1980. It covers 99,3% of all newborns in this area, the remaining are screened by more than 5 other laboratories. We follow up all cases of CH detected by our screening, either in our department or in collaboration with a local pediatrician. Since January 1980 we screened 95,657 out of 193,854 newborrsin this area. There were 879 recalls for serum with a declining recall rate from 2.23% in 1980 to 0.11% in 1987. Therapy and clinical follow-up was begun in 65 cases, of whom 30 were later considered transient hypothyroidism, 24 of them iodine-induced. Additional 4 children had transient, 2 so far permanent hypothyrotropinemia. The remaining 30 children are still under therapy (L-T4), therefore incidence of CH in our population is 1:3188. We saw seasonal variation in CH-incidence: 15 children were born between Jan. and April, 7 in Sept. and Oct. At about 2 years of age we reevaluate thyroid-function after disruption of T4 substitution, including scintigraphic scan, and intellectual and psychomotor developmental testing. Start of therapy in our patients was at day 6-33 (mean 13.3). Clinical follow-up of the children depicts insufficient L-Thyroxin substitution at one or more occasions in 80%. So far scintigraphic scan during follow-up showed 9 cases with athyreosis, 6 with ectopic thyroid tissue, and 3 with dyshormonogenesis. At age 2-4 mild deficiencies in intellectuel and psychomotor development could be demonstrated as a general trend in our patients, expressed as retardation in performance at or below the 90% level in a standardized testl. Severe retardation in 6 children (28%) as well as the milder forms was focussed on speech, perception, and less pronounced on fine motor abilities. Retardation showed no other correlation then with social status and severe additional illness.
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Authors and Affiliations
Klinik für Pädiatrie, Arbeitsgruppe Pädiatrische Endokrinologie, USA
C. Brack & P. Beyer
Biochem. Endokrinologie, Zentrales Hypothyreose-Screening für das Land SH, Medizinische Universität zu Lübeck, USA
G. Dinkelacker, H. P. Müller, P. Ball & R. Knuppen
Pediatric Endocrinology, Institute of Endocrinology Sheba Medical Center and Ministry of Health, Israel
J. Sack, M. Blum, Z. Raker, T. Tulchinsky, R. Gutekunst & A. Akstein
Hospital Infantil Vail d'Hebron, Universitat Autonoma, Barcelona, Spain
M. Albisu, N. Potau, A. Maya, M. Gussiner & E. Vicens-Calvet
National Institute for Preventive Health Care, Leiden, and Department of Pediatrics, University of, Amsterdam, The Netherlands
G. J. Vaandrager, T. Wilma, M. H. Gons & J. J. M. Vijlder
Department of Pediatrics, University of Amsterdam; National Institute for Preventive Health Care, Leiden, The Netherlands
T. Vulsma, G. J. Vaandrager, M. H. Gons & J. J. M. Vijlder
Laboratorio de Alteraciones Metabolico-Geneticas y Nutricionales. Dep. de Pediatria. Hosp. G. Galacia, Universidad de Santiago de Compostela. Xunta de Galicia, Conselleria de Sanidade e Seguridade Social. Programs Galego de Prevencion da Subnormalidade, Spain
C. Colon, J. R. Alonso-Fernandez, D. E. Castineiras, M. E. Romero, J. M. Fraga & J. Pena
Institute of Clinical Chemistry, Germany
G. Ackermann
Paediatric Clinic (School of Medicine), Germany
W. Ackernmsnn
Laboratory of Irr¢m.nology (Section 9f Bio-sciences), Karl-Marx-University, Leipiz, Germany
H. Willgerodt
VEB Sächsisches Serumwerk, Germany
H. Fiebig
Research Institute of Medical Diagnostics, Dresden, Germany
H. J. Thiele
C. Quebec Screening Network, Laval Medical Center, Ste Foy, Quebec, Canada
J. Morissette, N. Bélanger, P. Fiset, J. H. Dussault & C. Laberge
Sapporo City Institute of Public Health, Hakodate Central Hospital, Japan
M. Fukushi, O. Arai, Y. Mitzushima & N. Takasugi
Departrrent of Pediatrics, Hokkaido University School of Medicine, Japan
M. Eàndo & N. Matsuura
Department of Obstetrics, Hokkaido University School of Medicine, Japan
S. Fujimoto
Department of Molecular Endocrinology, USA
A. K. Sinha, A. Al-Mazidi, M. C. Ruiz Elvira & R. P. Ekins
Paediatric Endocrinology Unit, University College and Middlesex School of Medicine, Mortimer Street, London, WIN 8AA, USA
C. G. D. Brook
Department of Radioisotopes, St. Pieter Hospital and MRS Research Group, Free University of, Brussels, Belgium
M. Rubinstein, O. Jeghers, R. Mathur, C. Maerschalk & A. M. Errons
Depts. of Pediatrics and Internal Medicine, Free University, Berlin, Germany
A. Gruters, U. Bogner, H. Schleusener & H. Helge
Clinical Biochemistry Research Laboratory, Dept. of Medical Research, Veterans General Hospital, Taipei, Taiwan, 11217, China
K. J. Hsiao, M. J. Shieh, S. H. Chiang & F. Y. Su
Cattedra di Endocrinologia, University of Pisa, Pisa, Italy
L. Chiovato, F. L. Giusti, F. Santini, P. Bassi, P. Vitti, C. Marcocci, M. Tonacchera, M. Ciampi, G. F. Fenzi & A. Pinchera
Medical School, Dept. of Pediatrics, University of Mass, Worcester, M.A, USA
R. S. Brown, P. Keating & E. Mitchell
From the Departments of Pediatrics, SWeden
A. Ilirki & A. Larsson
Akademiska sjukhuset, Internal Medicine Unippsala University, Uppsala, SWeden
F. A. Karlssan
The PKU Section, National Bacteriological Laboratory, Stockholm, SWeden
A. Larsson
Department of Pediatric Endocrinology, Belgium
H. Capiau, R. Clara, J. P. Chanoine, M. Steppe, P. Bergmann, D. Biarent, M. H. Delaet, J. M. Bouton & F. Delange
Department of Genetics, Algemeen Kinderniekenhuis Antwerpen, Antwerp, Belgium
L. Roelen, M. Hayashi, M. Shimohira, S. Saisho, H. Suzuki, K. Shimozawa & Y. Iwakawa
Royal Manchester Children's Hospital, UK
G. M. Addison, M. Rosenthal, D. A. Price, R. Bellisario, L. J. Freligh, A. M. Wiley, M. L. Cower & M. R. Pandian
Istituto Superiore di Sanità, India
M. Carta Sorcini, S. Carta, A. Diodato, C. Fazzini, M. E. Grandolfo, R. Bruyn & D. B. Grant
Civil Hospital, Urbino, Italy
L. Donati, D. Eldar, O. Amado & J. Sack
Catholic University, India
C. Romagnoli, R. Luciano, F. Péter, L. Blatniczky & H. Breyer
Université Libre de Bruxelles, Belgium
P. Bourdoux, F. Delange, D. B. Grant, W. K. Ng, S. P. Leung & J. A. Hulse
Institue of Child Health, Athens, Greece
C. Mengreli, S. Pantelakis, J. Bovet, R. Ehrlich & D. Sorbara
Brussels University, Belgium
B. Swennen, J. Vanderpas, P. Abeele, J. Gillies, C. Thilly, A. Rickards, J. Coakley, I. Francis, S. Armstrong, H. Medson & J. Connelly
Department of Pediatrics, Academisch Ziekenhuis V.U.B, Brussels, Belgium
J. Schepper, D. Wolf, L. Smits, P. Fuggle, G. Murphy, G. Thorley & D. B. Grant
Hôpital Saint Vincent-de-Paul, Paris, France
J. E. Toublanc, S. Rives & J. C. Job
Hospital Infantil Vall d'Hebron, Univeristat Autonoma, Barcelona, Spain
L. Ibanez, M. Albisu, N. Potau, E. Vicens-Calvet & Catalan Collaborative Group
Scientific Institute H. San Rafaele, Dept. of Pediatrics Endocrine Unit, University of Milan, Italy
G. F. Rondanini, A. Bollati, V. Della Porta, R. Cerabolini, C. Lenti, L. Rovey, A. Manzoni & G. Chiumello
Istituto di Neuropsichiatria Infantile, Italy
S. Bargagna, L. Cittadoni, G. Falciglia, G. Ferretti & M. Marcheschi
Cattedra diEndocrinologia, University of Pisa, Pisa, Italy
L. Giovato, F. L. Giusti, G. F. Fenzi & A. Pinchera
Departments of Psychology and Pediatrics, Hospital for Sick Children, Toronto, Canada
D. Sorhara, J. Bovet & R. Ehrlich
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Editors and Affiliations
University of Brussels, Brussels, Belgium
François Delange & Daniel Glinoer &
Harbor-UCLA Medical Center, University of California, Los Angeles, Torrance, California, USA
Delbert A. Fisher
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Brack, C. et al. (1989). Abstracts of the Poster Sessions. In: Delange, F., Fisher, D.A., Glinoer, D. (eds) Research in Congenital Hypothyroidism. NATO ASI Series, vol 161. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7580-7_27
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