Abstract
The principal pathogen of acquired immunodeficiency syndrome (AIDS) in the United States is human immunodeficiency virus type 1 (HIV-1), but the disease is sometimes caused by a second variant, HIV-2. These two viruses share a similar genomic organization, indicating common evolutionary origin, but differ significantly in terms of nucleotide and amino-acid sequence, with no more than 60% overall amino-acid identity. Elucidation of the structures of virally-encoded enzymes offers an opportunity for rational drug design and has been pursued by many groups. The structure of only one enzyme encoded by HIV-1, that of the aspartyl protease (PR), is currently known (Navia et al., 1989; Wlodawer et al., 1989). This enzyme is essential for viral maturation, and is the target of choice for designing new therapeutic agents.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gustchina, A. & Weber, I. T., 1990. FEBS Lett. 269: 269–272.
Miller, M., Schneider, J., Sathyanarayana, B. K., Toth, M. V., Marshall, G. R., Clawson, L., Selk, L., Kent, S. B. H. & Wlodawer, A., 1989, Science 246: 1149–1152.
Navia, M. A., Fitzgerald, P. M. D., McKeever, B. M., Leu, C., Heimbach, J. C., Herber, W. K., Sigal, I. S., Darke, P. L. & Springer, J. P., 1989, Nature (London) 337: 615–620.
Richards, A. D., Roberts, R., Dunn, B. M., Graves, M. C. & Kay, J., 1989, FEBS Lett. 247: 113–117.
Richards, A. D., Broadhurst, A. V., Ritchie, A. J., Dunn, B. M. & Kay, J., 1990, FEBS Lett. 253: 214–216.
Swain, A. L., Miller, M., Green, J., Rich, D. H., Schneider, J., Kent, S. B. H. & Wlodawer, A., 1990, Proc. Natl. Acad. Sci. U.S.A. 87: 8805–8809.
Wlodawer, A., Miller, M., Jaskólski, M., Sathyanarayana, B. K., Baldwin, E., Weber, I. T., Selk, L. M., Clawson, L., Schneider, J. & Kent, S. B. H., 1989, Science 245: 616–621.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Gustchina, A., Weber, I.T., Wlodawer, A. (1991). Molecular Modeling of the HIV-2 Protease. In: Dunn, B.M. (eds) Structure and Function of the Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 306. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6012-4_75
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6012-4_75
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6014-8
Online ISBN: 978-1-4684-6012-4
eBook Packages: Springer Book Archive