Molecular Modeling of the HIV-2 Protease
The principal pathogen of acquired immunodeficiency syndrome (AIDS) in the United States is human immunodeficiency virus type 1 (HIV-1), but the disease is sometimes caused by a second variant, HIV-2. These two viruses share a similar genomic organization, indicating common evolutionary origin, but differ significantly in terms of nucleotide and amino-acid sequence, with no more than 60% overall amino-acid identity. Elucidation of the structures of virally-encoded enzymes offers an opportunity for rational drug design and has been pursued by many groups. The structure of only one enzyme encoded by HIV-1, that of the aspartyl protease (PR), is currently known (Navia et al., 1989; Wlodawer et al., 1989). This enzyme is essential for viral maturation, and is the target of choice for designing new therapeutic agents.
KeywordsAspartic Protease Renin Inhibitor Aspartyl Protease Rational Drug Design Common Evolutionary Origin
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