Structure and Function of the Aspartic Proteinases

Genetics, Structures, and Mechanisms

  • Ben M. Dunn

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Mammalian Gastric Proteinases: Plenary Lectures

    1. X. L. Lin, M. Fusek, Z. Chen, G. Koelsch, H. P. Han, J. A. Hartsuck et al.
      Pages 1-8
    2. Cele Abad-Zapatero, T. J. Rydel, D. J. Neidhart, J. Luly, J. W. Erickson
      Pages 9-21
    3. Gary L. Gilliland, Maureen Toner Oliva, Jonathan Dill
      Pages 23-37
    4. J. B. Cooper, M. P. Newman
      Pages 47-61
    5. Mark R. Martzen, Brad A. McMullen, Kazuo Fujikawa, Robert J. Peanasky
      Pages 63-73
    6. Petr Kuzmič, Chong-Qing Sun, Zhi-Cheng Zhao, Daniel H. Rich
      Pages 75-86
  3. Mammalian Gastric Proteinases: Poster Reports

    1. P. H. S. Meijerink, J. P. Bebelman, G. Pals, F. Arwert, R. J. Planta, A. W. Eriksson et al.
      Pages 87-90
    2. R. Thomas Taggart, Takeshi Azuma, S. Wu, Graeme I. Bell, Anne M. Bowcock
      Pages 95-99
    3. Asbjorn Gildberg, Ragnar L. Olsen, Jon B. Bjarnason
      Pages 107-110
    4. Guus Simons, Ger Rutten, Miranda Hornes, Monique Nijhuis, Martien van Asseldonk
      Pages 115-119
    5. Tönis Örd, Meelis Kolmer, Juhani Jänne, Richard Villems, Mart Saarma
      Pages 121-126
    6. Jože Pungerčar, Borut Štrukelj, Franc Gubenšek, Vito Turk, Igor Kregar
      Pages 127-131
    7. Chetana Rao, Paula E. Scarborough, W. Todd Lowther, John Kay, Brian Batley, Stephen Rapundalo et al.
      Pages 143-147

About this book


In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.


Mammalia enzymes protein

Editors and affiliations

  • Ben M. Dunn
    • 1
  1. 1.University of Florida-College of MedicineGainesvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-6014-8
  • Online ISBN 978-1-4684-6012-4
  • Series Print ISSN 0065-2598
  • About this book