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Structure and Function of the Aspartic Proteinases

Genetics, Structures, and Mechanisms

  • Ben M. Dunn

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Mammalian Gastric Proteinases: Plenary Lectures

    1. X. L. Lin, M. Fusek, Z. Chen, G. Koelsch, H. P. Han, J. A. Hartsuck et al.
      Pages 1-8
    2. Cele Abad-Zapatero, T. J. Rydel, D. J. Neidhart, J. Luly, J. W. Erickson
      Pages 9-21
    3. Gary L. Gilliland, Maureen Toner Oliva, Jonathan Dill
      Pages 23-37
    4. J. B. Cooper, M. P. Newman
      Pages 47-61
    5. Mark R. Martzen, Brad A. McMullen, Kazuo Fujikawa, Robert J. Peanasky
      Pages 63-73
    6. Petr Kuzmič, Chong-Qing Sun, Zhi-Cheng Zhao, Daniel H. Rich
      Pages 75-86
  3. Mammalian Gastric Proteinases: Poster Reports

    1. P. H. S. Meijerink, J. P. Bebelman, G. Pals, F. Arwert, R. J. Planta, A. W. Eriksson et al.
      Pages 87-90
    2. R. Thomas Taggart, Takeshi Azuma, S. Wu, Graeme I. Bell, Anne M. Bowcock
      Pages 95-99
    3. Asbjorn Gildberg, Ragnar L. Olsen, Jon B. Bjarnason
      Pages 107-110
    4. Guus Simons, Ger Rutten, Miranda Hornes, Monique Nijhuis, Martien van Asseldonk
      Pages 115-119
    5. Tönis Örd, Meelis Kolmer, Juhani Jänne, Richard Villems, Mart Saarma
      Pages 121-126
    6. Jože Pungerčar, Borut Štrukelj, Franc Gubenšek, Vito Turk, Igor Kregar
      Pages 127-131
    7. Chetana Rao, Paula E. Scarborough, W. Todd Lowther, John Kay, Brian Batley, Stephen Rapundalo et al.
      Pages 143-147
  4. Microbial Aspartic Proteinases: Plenary Lectures

    1. Michael Ward, Katherine H. Kodama
      Pages 149-160
    2. Vivian L. MacKay, Jacque Armstrong, Carli Yip, Susan Welch, Kathy Walker, Sherri Osborn et al.
      Pages 161-172
    3. Thomas L. Ray, Candia D. Payne, Brian J. Morrow
      Pages 173-183
    4. Kohei Oda, Sawao Murao
      Pages 185-201
    5. Kenji Takahashi, Masaru Tanokura, Hideshi Inoue, Masaki Kojima, Yutaka Muto, Makoto Yamasaki et al.
      Pages 203-211
    6. Kevin D. Parris, Dennis J. Hoover, David R. Davies
      Pages 217-231
    7. Jun-ichi Aikawa, Ryuji Hiramatsu, Makoto Nishiyama, Sueharu Horinouchi, Teruhiko Beppu
      Pages 233-242
    8. Theo Hofmann, Max Blum, Annie Cunningham
      Pages 243-254
  5. Microbial Aspartic Proteinases: Poster Reports

    1. Xinli Lin, Martin Fusek, Jordan Tang
      Pages 255-257
    2. Steen B. Mortensen, Claus Dambmann
      Pages 259-263
    3. Dennis J. Hoover, Balusubramanian Veerapandian, Jon B. Cooper, David B. Damon, Beryl W. Dominy, Robert L. Rosati et al.
      Pages 269-273
    4. W. Todd Lowther, Zhong Chen, Xin-li Lin, Jordan Tang, Ben M. Dunn
      Pages 275-279
  6. Non-Gastric Mammalian Proteinases: Plenary Lectures

    1. Janice S. Blum, Maria L. Fiani, Philip D. Stahl
      Pages 281-287
    2. Gary Richo, Gregory E. Conner
      Pages 289-296
    3. Kenji Yamamoto, Hideaki Sakai, Eiko Ueno, Yuzo Kato
      Pages 297-306
    4. Peter D. Williams, Linda S. Payne, Debra S. Perlow, M. Katharine Holloway, Peter K. S. Siegl, Terry W. Schorn et al.
      Pages 325-334
  7. Non-Gastric Mammalian Proteinases: Poster Reports

    1. Deepali Sachdev, Jeff Schorey, John Chirgwin
      Pages 335-338
    2. Jeff Schorey, John Chirgwin
      Pages 339-342
    3. Paula E. Scarborough, Gary R. Richo, John Kay, Gregory E. Conner, Ben M. Dunn
      Pages 343-347
    4. M. Mareš, M. Fusek, V. Kostka, M. Baudyš
      Pages 349-353
    5. K. Törmäkangas, P. Runeberg-Roos, A. Östman, C. Tilgmann, P. Sarkkinen, J. Kervinen et al.
      Pages 355-359
    6. Hideaki Sakai, Takashi Saku, Yuzo Kato, Kenji Yamamoto
      Pages 361-364
    7. A. F. Kisseljov, S. V. Gulnik, N. I. Tarasova
      Pages 369-371
    8. J. A. Norman, R. Baska, O. Hadjilambris, D. Youngsharp, R. Kumar
      Pages 373-377
    9. K. F. Geoghegan, A. J. Lanzetti, M. J. Ammirati, D. E. Danley, B. A. O’Connor, P. M. Hobart
      Pages 379-381

About this book

Introduction

In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.

Keywords

Mammalia enzymes protein

Editors and affiliations

  • Ben M. Dunn
    • 1
  1. 1.University of Florida-College of MedicineGainesvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-6012-4
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-6014-8
  • Online ISBN 978-1-4684-6012-4
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site