Studies of the Autoprocessing of the HIV-1 Protease Using Cleavage Site Mutants
The distinguishing features of aspartyl proteases in retroviruses, vis à vis the semi-symmetrical aspartyl proteases in other organisms, is the paucity of the genetic information in the viruses sufficient for the synthesis of a monomelic protein, from which the homodimer is assembled with the formation of the characteristic active site structure.1
KeywordsFusion Protein Aspartyl Protease Active Site Structure Urea Denaturation Refold Procedure
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