Colonization of The Murine Gastrointestinal Tract by Salmonella typhimurium
Salmonella infection of animal hosts results, in general, from oral consumption of contaminated foods. It is therefore important to understand the series of events necessary for Salmonella to exist both outside and inside the host. We have set out to define biochemically and genetically the gene products necessary for S. typhimurium to traffic through the animal host and also to determine how S. typhimurium regulates the expression of these genes in response to the changing environmental niches occupied during transit through this infection pathway. Ultimately, information from such studies should be useful in the design and construction of attenuated Salmonella derivatives to use for immunization to prevent infection.
KeywordsIntestinal Colonization Component Regulatory System Salmonella TYPHIMURIUM Outer Membrane Porin Protein phoP Mutant
Unable to display preview. Download preview PDF.
- 1).Galan, J. E., and R. Curtiss III. 1989. Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells. Proc. Nat. Acad. Sci. USA. 86:6383–6387.Google Scholar
- 4).Galan, J. E., and Roy Curtiss III. 1990. Expression of Salmonella genes required for invasion is regulated by changes in DNA supercoiling. Infect. Immune. 59:1879–1885.Google Scholar
- 8).Cairney, J., I. R. Booth, and C. F. Higgins. 1986. Osmoregulation of gene expression in Salmonella typhlmurium: proU encodes an osmotically induced betaine transport system. J. Bacteriol. 164: 1224–1232.Google Scholar