On the Cytotoxic Modes of Action of Clostridium difficile Toxins
Clostridium difficile, the major aetiological agent of antibiotic associated colitis, produces two high molecular weight protein toxins, designated as toxins A and B, which are involved in the pathogenesis of the disease1. Toxin A is an enterotoxin which induces hemorrhagic fluid secretion and tissue necrosis in intestinal loops. Toxin B lacks these activities. Both are cytotoxins which act intracellularly2,3 although the mechanisms involved in the cytotoxic effects are unknown.
KeywordsClostridium Difficile Inositol Phosphate Human Lung Fibroblast Intracellular Calcium Release Human Embryonic Lung Fibroblast
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