Abstract
Large numbers of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isozymes have been found in humans and other mammals. These enzymes oxidize varieties of alcohols and aldehydes, and play a role, not only in alcohol detoxification, but also in the metabolism of drugs, neurotransmitters and other endogenous biologically active alcohols and aldehydes.
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Farrds, J., Guan, K., and Weiner, H., 1989, Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenase deduced from cDNA sequences, Eur.J.Bioch., 180: 67.
Frezza, M., di Padova, C., Possato, G., Terpin, M., Baraona, E., and Lieber, C. S., 1990, High blood alcohol levels in women: The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism, New Eng.J.Med., 322: 95.
Hsu, L. C., Tani, K., Fujiyoshi, T., Kurachi, K., and Yoshida, A., 1985, Cloning of cDNAs for human aldehyde dehydrogenase 1 and 2, Proc. Natl.Acad.Sci.U.S.A., 82: 3771.
Hsu, L. C., Bendel, R. E., and Yoshida, A., 1988, Genomic structure of the human mitochondrial aldehyde dehydrogenase gene, Genomics, 2: 57.
Hsu, L. C., Chang, W-C., and Yoshida, A., 1989a, Genomic structure of the human cytosolic aldehyde dehydrogenase gene, Genomics, 5: 857.
Hsu, L. C., Chang, W-C., and Yoshida, A., 1989b, Cloning of a new human aldehyde dehydrogenase gene and comparison with liver cytosolic ALDH1 and mitochondrial ALDH2 genes, Am.J.Hum.Genet., 45: A196.
Ikuta, T., Szeto, S., and Yoshida, A., 1986, Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence, Proc.Natl.Acad.Sci.U.S.A., 83: 634.
Jörnvall, H., Höög, J-O., von Bahr-Lindström, H., Johansson, J., Kaizer, R., and Persson, B., 1987, Alcohol dehydrogenases and aldehyde dehydrogenases, Bioch.Soc.Trans., 16: 223.
Keung, W-M., 1988, A genuine organ specific alcohol dehydrogenase from hamster testes: Isolation, characterization and developmental changes, Bioch.Biophys.Res.Comm., 156: 38.
McCarrey, J. R., and Thomas, K., 1987, Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene, Nature, 326: 501.
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., and Erlich, H. A., 1988, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase, Science, 239: 487.
Yoshida, A., Hsu, L. C., and Yasunami, M., 1990, Genetics of human alcohol-metabolizing enzymes, in: “Progress in Nucleic Acid Research and Molecular Biology,” W. Cohn and K. Moldave, eds., Academic Press, Orlando, in press.
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© 1991 Plenum Press, New York
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Yoshida, A., Hsu, L., Yasunami, M. (1991). Cloning and Characterization of New Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes. In: Palmer, T.N. (eds) Alcoholism. NATO ASI Series, vol 206. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5946-3_9
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DOI: https://doi.org/10.1007/978-1-4684-5946-3_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5948-7
Online ISBN: 978-1-4684-5946-3
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