Genetic Linkage Analysis: Simple Solutions for Complex Traits?
Many human disorders are either partially or wholly determined by genetic factors. The identification of these genetic defects at the DNA level is a major goal with important implications. Such identification could greatly increase our understanding of diseases whose pathophysiology and clinical course are currently unknown. In turn, this could lead to logical improvements in the way the disorder is treated. Furthermore, antenatal diagnosis and the identification of carriers could provide the opportunity for more accurate genetic counseling.
KeywordsLinkage Analysis Complex Trait Tuberous Sclerosis Duchenne Muscular Dystrophy Familial Aggregation
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