Immunopathogenesis of Demyelination Induced by MHV-4
Mouse hepatitis virus-4 (MHV-4 or JHM) is a murine Coronavirus which causes central nervous system (CNS) demyelination in rodents (1). Experimental MHV-4 infection has been used as a model of human demyelinating diseases, such as multiple sclerosis. One of the major questions relating to MHV-4 pathogenesis is the degree to which demyelination caused by this virus is due either to 1) direct viral cytopathology, especially for oligodendrocytes, the cells which produce and maintain myelin, or 2) immunological responses elicited by viral infection.
KeywordsViral Antigen Adoptive Transfer Demyelinating Disease Keyhole Limpet Hemocyanin Mouse Hepatitis Virus
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