Immunopathogenesis of Demyelination Induced by MHV-4

  • J. O. Fleming
  • F. I. Wang
  • M. D. Trousdale
  • D. R. Hinton
  • S. A. Stohlman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Mouse hepatitis virus-4 (MHV-4 or JHM) is a murine Coronavirus which causes central nervous system (CNS) demyelination in rodents (1). Experimental MHV-4 infection has been used as a model of human demyelinating diseases, such as multiple sclerosis. One of the major questions relating to MHV-4 pathogenesis is the degree to which demyelination caused by this virus is due either to 1) direct viral cytopathology, especially for oligodendrocytes, the cells which produce and maintain myelin, or 2) immunological responses elicited by viral infection.


Viral Antigen Adoptive Transfer Demyelinating Disease Keyhole Limpet Hemocyanin Mouse Hepatitis Virus 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. O. Fleming
    • 1
    • 2
  • F. I. Wang
    • 1
    • 2
  • M. D. Trousdale
    • 2
    • 4
  • D. R. Hinton
    • 3
  • S. A. Stohlman
    • 1
    • 2
  1. 1.Department of NeurologyUniversity of Southern California Medical SchoolLos AngelesUSA
  2. 2.Department of MicrobiologyUniversity of Southern California Medical SchoolLos AngelesUSA
  3. 3.Department of PathologyUniversity of Southern California Medical SchoolLos AngelesUSA
  4. 4.Estelle Doheny Eye InstituteUniversity of Southern California Medical SchoolLos AngelesUSA

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