Immunopathogenesis of Demyelination Induced by MHV-4
Mouse hepatitis virus-4 (MHV-4 or JHM) is a murine Coronavirus which causes central nervous system (CNS) demyelination in rodents (1). Experimental MHV-4 infection has been used as a model of human demyelinating diseases, such as multiple sclerosis. One of the major questions relating to MHV-4 pathogenesis is the degree to which demyelination caused by this virus is due either to 1) direct viral cytopathology, especially for oligodendrocytes, the cells which produce and maintain myelin, or 2) immunological responses elicited by viral infection.
KeywordsHepatitis Neurol Cyclosporin Cyclophosphamide Hematoxylin
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- 1.H. Wege, S. Siddell, and V. ter Meulen: The biology and pathogenesis of coronaviruses. Curr. Top. Microbiol. Immunol. 99:265–200 (1982).Google Scholar
- 10.R.L. Knobler, M. Dubois-Dalcq, M.V. Haspel, A.P. Claysmith, P.W. Lampert, and M.B.A. Oldstone: Selective localization of wild type and mutant mouse hepatitis virus (JHM strain) antigens in CNS tissue by fluorescence, light and electron microscopy. J. Neuroimmunol. 1:81–92 (1981).PubMedCrossRefGoogle Scholar