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Coronaviruses and their Diseases

  • David Cavanagh
  • T. David K. Brown

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes

    1. D. Cavanagh, D. Brian, L. Enjuanes, K. Holmes, M. Lai, H. Laude et al.
      Pages 1-2
  3. The Spike (S) Glycoprotein

    1. Front Matter
      Pages 3-3
    2. Kathryn V. Holmes, Richard K. Williams
      Pages 5-7
    3. H. Vennema, P. J. M. Rottier, L. Heijnen, G. J. Godeke, M. C. Horzinek, W. J. M. Spaan
      Pages 9-19
    4. Kathryn V. Holmes, Richard K. Williams, Christine B. Cardellichio, Susan R. Compton, Charles B. Stephensen, Stuart W. Snyder et al.
      Pages 37-44
    5. Richard K. Williams, Stuart W. Snyder, Kathryn V. Holmes
      Pages 45-50
    6. Emilia L. Oleszak, Julian L. Leibowitz
      Pages 51-58
    7. Nathalie Arpin, Pierre J. Talbot
      Pages 73-80
    8. Pascal Boireau, Nathalie Woloszyn, Catherine Crucière, Ericka Savoysky, Jacques Laporte
      Pages 81-88
  4. The Haemagglutinin-Esterase (HE) and Membrane (M) Glycoproteins

    1. Front Matter
      Pages 89-89
    2. Thomas E. Kienzle, Sushma Abraham, Brenda G. Hogue, David A. Brian
      Pages 95-102
    3. Michael D. Parker, Graham J. Cox, Dongwan Yoo, David R. Fitzpatrick, Lorne A. Babiuk
      Pages 103-108
    4. Beate Schultze, R. Günter Heβ, Rudolf Rott, Hans-Dieter Klenk, Georg Herrler
      Pages 109-113
    5. Beate Schultze, Hans-Jürgen Groβ, Hans-Dieter Klenk, Reinhard Brossmer, Georg Herrler
      Pages 115-119
    6. P. J. M. Rottier, J. Krijnse Locker, M. C. Horzinek, W. J. M. Spaan
      Pages 127-135
  5. B- and T-Cell Epitopes of the Structural Proteins

    1. Front Matter
      Pages 137-137
    2. L. Enjuanes, F. Gebauer, I. Correa, M. J. Bullido, C. Suñé, C. Smerdou et al.
      Pages 159-172
    3. Willem P. A. Posthumus, Rob H. Meloen, Luis Enjuanes, Isabel Correa, Anthonie P. van Nieuwstadt, Guus Koch et al.
      Pages 181-188
    4. Annemieke M. H. Boots, Johannes G. Kusters, Bernard A. M. van der Zeijst, Evert J. Hensen
      Pages 189-197
  6. Expression and Immunogenicity of the Structural Proteins

    1. Front Matter
      Pages 199-199
    2. Fumihiro Taguchi, Sayaka Yoden, Stuart Siddell, Tateki Kikuchi
      Pages 211-216
    3. Harry Vennema, Raoul J. de Groot, David A. Harbour, Mieke Dalderup, Tim Gruffydd-Jones, Marian C. Horzinek et al.
      Pages 217-222
    4. D. J. Pulford, P. Britton, K. W. Page, D. J. Garwes
      Pages 223-232
  7. The Nucleocapsid (N) Protein

  8. The Polymerase and other Non-Structural Proteins

    1. Front Matter
      Pages 267-267
    2. I. Brierley, M. E. G. Boursnell, M. M. Binns, B. Bilimoria, N. J. Rolley, T. D. K. Brown et al.
      Pages 275-281
    3. Susan C. Baker, Nicola La Monica, Chien-Kou Shieh, Michael M. C. Lai
      Pages 283-289
    4. Philip W. Zoltick, Julian L. Leibowitz, James DeVries, Catherine J. Pachuk, Susan R. Weiss
      Pages 291-299
    5. Peter J. Bredenbeek, Eric J. Snijder, Ans F. H. Noten, Johan A. den Boon, Wim M. M. Schaaper, Marian C. Horzinek et al.
      Pages 307-316
    6. Birgit Schwarz, Edward Routledge, Stuart Siddell
      Pages 317-324

About these proceedings

Introduction

Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.

Keywords

Enteritis antigen central nervous system cloning diseases genome infection membrane mouse nervous system pathology peptides proteins virology virus

Editors and affiliations

  • David Cavanagh
    • 1
  • T. David K. Brown
    • 2
  1. 1.AFRC Institute for Animal HealthHuntingdonUK
  2. 2.Department of PathologyUniversity of CambridgeUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5823-7
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5825-1
  • Online ISBN 978-1-4684-5823-7
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site