Abstract
Murine hepatitis virus 4 (MHV-4) is a neurotropic Coronavirus (1–4). Infection of the CNS in susceptible mice strains results in a fatal encephalitis with destruction of neurons accompanied by demyelination. The few mice that survive the acute infection develop a chronic demyelinating disease characterized by episodes of demyelination followed by remyelination (2,5). The extensive white matter disease is believed to arise as the consequence of viral infection and destruction of oligodendrocytes (2,3,6).
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Keywords
- Mouse Hepatitis Virus
- Fatal Encephalitis
- Susceptible Mouse Strain
- Hepatitis Virus Type
- Chronic Demyelinating Disease
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© 1990 Plenum Press, New York
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Parker, S.E., Buchmeier, M.J. (1990). RNA Sequence Analysis of the E2 Genes of Wildtype and Neuroattenuated Mutants of MHV-4 Reveals a Hypervariable Domain. In: Cavanagh, D., Brown, T.D.K. (eds) Coronaviruses and their Diseases. Advances in Experimental Medicine and Biology, vol 276. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5823-7_54
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DOI: https://doi.org/10.1007/978-1-4684-5823-7_54
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