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Pro- and Anti-Oxidant Factors in Rat lung Cytosol

  • Cornelis J. A. Doelman
  • Aalt Bast
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

During the process of inflammation oxygen radicals are produced by phagocytic cells like neutrophils, eosinophils, monocytes and macrophages. Little is known about the effects of oxygen radicals on lung tissue in inflammatory diseases such as asthma1. Activated phagocytes release Superoxide anions, synthesized by NADPH oxidase which is located in the cellular membrane. Superoxide anions dismutate to hydrogen peroxide enzymatically (superoxide dismutase) or non-enzymatically. These superoxide anions and hydrogen peroxide together form very reactive oxygen species, namely the hydroxyl radical and singlet oxygen. In these reactions iron plays a catalytic role2. Oxygen metabolites cause DNA strand breaks, protein destruction (particularly sulfhydryl groups are sensitive to oxidative stress) and lipid peroxidation. The lipid peroxidation reaction products are very toxic too and cause DNA and protein damage as well3,4.

Keywords

Lipid Peroxidation Glutathione Peroxidase Glutathione Reductase Cumene Hydroperoxide Microsomal Lipid Peroxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Cornelis J. A. Doelman
    • 1
  • Aalt Bast
    • 1
  1. 1.Department of Pharmacochemistry, Faculty of ChemistryVrije UniversiteitAmsterdamThe Netherlands

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