Abstract
The evidence for the participation of O -2 in many biological processes has been grown rapidly since the discovery of Superoxide dismutase (SOD) by McCord and Fridovich in 1969.1 It has been demonstrated, in numerous systems, that O -2 exhibits deleterious properties and is a very toxic entity.2,3
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.M. McCord, and I. Fridovich, Superoxide dismutase: an enzymatic function for erythrocuprein. J. BioL Chem. 244:6049 (1969).
I. Fridovich, Superoxide radical and Superoxide dismutase.Acc. Chem. Res.5:321 (1972).
G. Czapski, S. Goldstein, and D. Meyerstein, What is unique about Superoxide toxicity as compared to other biological reductants? A hy pothesis. Free Rad. Res. Comm. 4:231 (1988).
J.M. McCord, Free radicals and myocardial Ischemia: overview and outlook. Free Radical Biol. Med. 4:9 (1988).
T. Miura, D.M. Yellon, J. Kingma, and J.M. Downey, Protection afforded by Allopurinol in the first 24 hours of coronary occlusion is diminished after 48 hours. ibid. 4:25 (1988).
A.S. Manning, Reperfusion-induced Arrhythmias: Do free radicals play a critical role? ibid. 4:305 (1988).
S. Goldstein, and G. Czapski, The role and mechanism of metal ions and their complexes in enhancing damage in biological systems or in protecting these systems from the toxicity of O-2 ibid. 2:3 (1986).
A. Samuni, C. Murali Krishna, P. Riesz, E. Finkelstein, and A. Russo, A novel metal-free low molecular weight Superoxide dismutase mimic. J. Biol. Chem. 263:17921 (1988).
JJ. Berzelius, Jahresber. Chem. 15:237 (1836).
R.P. Bell, Acid Base Catalysis. Clarendon Press, Oxford (1941).
G. Czapski, and S. Goldstein, The uniqueness of Superoxide dismutase (SOD). Why cannot most copper compounds substitute SOD in vivo? Free Rad. Res. Comm. 4:225 (1988).
S. Goldstein, C. Michel, W. Bors, M. Saran and G. Czapski, A critical revaluation of some assay methods for Superoxide dismutase activity. Free Radical. Biol. and Med., 4:295 (1988).
J. Aronovitch, A. Samuni, D. Godinger, and G. Czapski, In vivo degradation of bacterial DNA by H2O2 and by o-phenanthroline in Super oxide and Superoxide Dismutase in Chemistry, Biology and Medicine; G. Rotilio, editor, p. 346, Elsevier Science Publishers, B.V., (1986).
S. Goldstein, and G. Czapski, Mechanism and reaction of some copper complexes in the presence of DNA with O-2 H2O2 and molecular oxygen. J. Am. Chem. Soc. 108:2244 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Czapski, G., Goldstein, S. (1990). Superoxide Scavengers and SOD or SOD Mimics. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_7
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5730-8_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5732-2
Online ISBN: 978-1-4684-5730-8
eBook Packages: Springer Book Archive