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Direct Measurement of Free Radical Generation in Isolated Rat Heart by Electron Paramagnetic Resonance Spectroscopy : Effect of Trimetazidine

  • Véronique Maupoil
  • Luc Rochette
  • Alain Tabard
  • Pascale Clauser
  • Catherine Harpey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

Free radicals species have been implicated as important agents involved in myocardium ischemia and reperfusion injuries (Mac Cord, 1985). The major cytotoxic effect of oxygen-derivated free radicals may be peroxidation of lipid components of cellular membranes which may be an important process for cell damage during myocardial infarction. In this study, Electron Paramagnetic Resonance Spectroscopy (EPR) was used to directly mesure free radical generation in isolated perfused rat hearts (Maupoil and Rochette, 1988). We also investigated the formation of thiobarbituric acid reactants as an index of lipid peroxidation. The effect of TMZ in the postischemic heart was determined.

Keywords

Electron Paramagnetic Resonance Electron Paramagnetic Resonance Spectrum Free Radical Generation Electron Paramagnetic Resonance Spectroscopy Isolate Rabbit Heart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Véronique Maupoil
    • 1
  • Luc Rochette
    • 1
  • Alain Tabard
    • 2
  • Pascale Clauser
    • 3
  • Catherine Harpey
    • 3
  1. 1.Laboratoire de PharmacodynamieFaculté de PharmacieDijonFrance
  2. 2.Laboratoire de Chimie des HétérocyclesFaculté des SciencesDijonFrance
  3. 3.IRIS Neuilly sur SeineFrance

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