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Direct Measurement of Free Radical Generation in Isolated Rat Heart by Electron Paramagnetic Resonance Spectroscopy : Effect of Trimetazidine

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Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

Free radicals species have been implicated as important agents involved in myocardium ischemia and reperfusion injuries (Mac Cord, 1985). The major cytotoxic effect of oxygen-derivated free radicals may be peroxidation of lipid components of cellular membranes which may be an important process for cell damage during myocardial infarction. In this study, Electron Paramagnetic Resonance Spectroscopy (EPR) was used to directly mesure free radical generation in isolated perfused rat hearts (Maupoil and Rochette, 1988). We also investigated the formation of thiobarbituric acid reactants as an index of lipid peroxidation. The effect of TMZ in the postischemic heart was determined.

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Author information

Authors and Affiliations

  1. Laboratoire de Pharmacodynamie, Faculté de Pharmacie, Dijon, France

    Véronique Maupoil & Luc Rochette

  2. Laboratoire de Chimie des Hétérocycles, Faculté des Sciences, Dijon, France

    Alain Tabard

  3. IRIS Neuilly sur Seine, France

    Pascale Clauser & Catherine Harpey

Authors
  1. Véronique Maupoil
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  2. Luc Rochette
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  3. Alain Tabard
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  4. Pascale Clauser
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  5. Catherine Harpey
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

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© 1990 Plenum Press, New York

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Maupoil, V., Rochette, L., Tabard, A., Clauser, P., Harpey, C. (1990). Direct Measurement of Free Radical Generation in Isolated Rat Heart by Electron Paramagnetic Resonance Spectroscopy : Effect of Trimetazidine. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_58

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  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_58

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5732-2

  • Online ISBN: 978-1-4684-5730-8

  • eBook Packages: Springer Book Archive

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