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Insulin-Like Growth Factor Receptors in the Central Nervous System: Phosphorylation Events and Cellular Mediators of Biological Function

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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

Abstract

A complex pattern of growth and development in the nervous system would seem inherent in consideration of its morphological design for control of physiological processes and psychological phenomena. Yet in spite of this tangled design it would appear reasonable that certain basics tenets must be preserved in development and growth in the cellular world. Using such reasoning, the complex mechanisms responsible for growth and development in the nervous system have begun to acquire a very rudimentary definition. It has become increasingly apparent that a functional family of peptides termed growth factors are basic to the regulation of growth and development in peripheral cell populations (Daughaday, 1989). Recent research addressing nervous system growth and development points at these same peptide factors as important determinants in the generation and maintenance of the distinct cell types that comprise the brain, peripheral nerves, and organs of neural ectodermal origin.

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Authors and Affiliations

  1. Department of Physiology, University of Florida, Gainesville, FL, 32610, USA

    Brian A. Masters & Mohan K. Raizada

  2. Section of Molecular and Cellular Physiology, Diabetes Branch, NIADDK, National Institutes of Health, Bethesda, MD, 20892, USA

    Joshua Shemer & Derek LeRoith

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  1. Brian A. Masters
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  2. Joshua Shemer
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  4. Mohan K. Raizada
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Masters, B.A., Shemer, J., LeRoith, D., Raizada, M.K. (1989). Insulin-Like Growth Factor Receptors in the Central Nervous System: Phosphorylation Events and Cellular Mediators of Biological Function. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_29

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_29

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