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Evidence for Central Nervous System Insulin Synthesis

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Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

Abstract

Since Havrankonva and co-workers described the widespread distribution of both insulinl and insulin receptors2 in the rat central nervous system (CNS), two basic questions have remained unanswered. The first is the source of this insulin within the CNS, whether locally produced or of pancreatic origin. Second is the function of insulin within the CNS. Does insulin have similar effects. centrally to those outside the CNS or does insulin have unique functions in the CNS?

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Author information

Authors and Affiliations

  1. Departments of Pediatrics, University of Florida College of Medicine, Gainesville, FL, 32610, USA

    Derrel W. Clarke & Jennifer J. Poulakos

  2. Departments of Physiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA

    Laura M. Mudd & Mohan K. Raizada

  3. Departments of Pathology, University of Florida College of Medicine, Gainesville, FL, 32610, USA

    David L. Cooper

Authors
  1. Derrel W. Clarke
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  2. Jennifer J. Poulakos
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  3. Laura M. Mudd
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  4. Mohan K. Raizada
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  5. David L. Cooper
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Editor information

Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada  & M. Ian Phillips  & 

  2. Diabetes Branch, NIDDK, NIH, Bethesda, Maryland, USA

    Derek LeRoith

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© 1987 Plenum Press, New York

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Clarke, D.W., Poulakos, J.J., Mudd, L.M., Raizada, M.K., Cooper, D.L. (1987). Evidence for Central Nervous System Insulin Synthesis. In: Raizada, M.K., Phillips, M.I., LeRoith, D. (eds) Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5380-5_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5380-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5382-9

  • Online ISBN: 978-1-4684-5380-5

  • eBook Packages: Springer Book Archive

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