S-Adenosylmethionine Decarboxylase from Escherichia Coli and from Saccharomyces Cerevisiae: Cloning and Overexpression of the Genes
S-Adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of spermidine and spermine in both prokaryotes and eukaryotes.1 We first detected this enzyme in our initial studies on the biosynthesis of spermidine in E. coli2, 3; subsequently S-adenosylmethionine decarboxylase has been found widely distributed in bacteria, fungi, plants, and animal cells. The enzyme has been purified to homogeneity from E. coli,4, 5S. cerevisiae,6, 7 liver,8, 9 lymphocytes,11 and mammary gland.12
KeywordsReductive Amination Histidine Decarboxylase Methionine Adenosyltransferase Proenzyme Form Protein Cleavage Site
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