Progress in Polyamine Research

Novel Biochemical, Pharmacological, and Clinical Aspects

  • Vincenzo Zappia
  • Anthony E. Pegg

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Ornithine Decarboxylase: Molecular Genetics, Post-Synthetic Modifications and Antizyme

    1. Front Matter
      Pages xv-xv
    2. Olli A. Jänne, Anne Crozat, Mervi Julkunen, Noreen J. Hickok, Leonard Eisenberg, Evie Melanitou
      Pages 1-11
    3. C. A. Panagiotidis, S. C. Huang, S. A. Tsirka, D. A. Kyriakidis, E. S. Canellakis
      Pages 13-24
    4. S. Hayashi, Y. Murakami, S. Matsufuji, M. Nishiyama, R. Kanamoto, T. Kameji
      Pages 25-35
    5. Margaret E. Brosnan, Yu-Wan Hu
      Pages 37-43
    6. Flavio Flamigni, Flavio Meggio, Sandra Marmiroli, Carlo Guarnieri, Lorenzo A. Pinna, Claudio M. Caldarera
      Pages 45-53
    7. J. L. A. Mitchell, M. F. Hicks, H. J. Chen, J. A. Hoff
      Pages 55-70
  3. Enzymes of Polyamine Metabolism and Recycling

    1. Front Matter
      Pages 71-71
    2. Giovanna Cacciapuoti, Marina Porcelli, Agata Gambacorta, Teresa Romano, Mario De Rosa
      Pages 91-100
    3. Anthony E. Pegg, Bruce Stanley, Antti Pajunen, Anne Crozat, Olli A. Jänne
      Pages 101-109
    4. Terho Eloranta, Olavi Kajander, Leila Kauppinen, Tapani Hyvönen, Annikka Linnala-Kankkunen, Nisse Kalkkinen et al.
      Pages 117-126
  4. Metabolism of 5′ -Methylthioadenosine in Normal and Transformed Cells

    1. Front Matter
      Pages 163-163
    2. Vincenzo Zappia, Fulvio Della Ragione, Gabriele Pontoni, Vincenzo Gragnaniello, Maria Cartenì-Farina
      Pages 165-177
    3. Dennis A. Carson, Tsutomu Nobori, E. Olavi Kajander, Carlos J. Carrera, Masaru Kubota, Hisashi Yamanaka
      Pages 179-185

About this book

Introduction

This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.

Keywords

biochemistry biology enzyme enzymes molecular biology synthesis transcription translation

Editors and affiliations

  • Vincenzo Zappia
    • 1
  • Anthony E. Pegg
    • 2
  1. 1.Institute of Biochemistry of MacromoleculesUniversity of NaplesNaplesItaly
  2. 2.The Milton S. Hershey Medical CenterThe Pennsylvania State UniversityHersheyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5637-0
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5639-4
  • Online ISBN 978-1-4684-5637-0
  • Series Print ISSN 0065-2598
  • About this book