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Deoxyhypusine Hydroxylase

  • A. Abbruzzese
  • V. Liguori
  • M. H. Park
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)

Abstract

The unusual basic amino acid hypusine [Nε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine which was originally isolated from a trichloroacetic acid-soluble extract of bovine brain (1). Subsequently it was found that in its free form hypusine concentration is highest in the brain (2), whereas, as a protein component, testes are the richest source (3). Furthermore, in developing rats, the hypusine concentration in brain protein is higher in the first 2 weeks of postnatal life and then steadily decreases until adulthood (3). In this organ the amino acid is also present bound to γ-aminobutyric acid (GABA) (4).

Keywords

Tritiated Water Picolinic Acid Polyamine Spermidine Deoxyhypusine Hydroxylase Polyamine Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. Abbruzzese
    • 1
  • V. Liguori
    • 1
  • M. H. Park
    • 2
  1. 1.Dipartimento di Biochimica e BiofisicaUniversita di NapoliItaly
  2. 2.National Institute of Dental ReserachNIHBethesdaUSA

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