The unusual basic amino acid hypusine [Nε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine which was originally isolated from a trichloroacetic acid-soluble extract of bovine brain (1). Subsequently it was found that in its free form hypusine concentration is highest in the brain (2), whereas, as a protein component, testes are the richest source (3). Furthermore, in developing rats, the hypusine concentration in brain protein is higher in the first 2 weeks of postnatal life and then steadily decreases until adulthood (3). In this organ the amino acid is also present bound to γ-aminobutyric acid (GABA) (4).
KeywordsTritiated Water Picolinic Acid Polyamine Spermidine Deoxyhypusine Hydroxylase Polyamine Research
Unable to display preview. Download preview PDF.
- 17.A. Abbruzzese, T. Isernia, V. Liguori, and S. Beninati, Polyamine-dependent post-translational modification of protein and cell proliferation, Perspectives in Polyamine Research (A. Perin, G. Scalabrino, M.E. Feriolo, eds) (in press).Google Scholar