Deoxyhypusine Hydroxylase

  • A. Abbruzzese
  • V. Liguori
  • M. H. Park
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


The unusual basic amino acid hypusine [Nε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine which was originally isolated from a trichloroacetic acid-soluble extract of bovine brain (1). Subsequently it was found that in its free form hypusine concentration is highest in the brain (2), whereas, as a protein component, testes are the richest source (3). Furthermore, in developing rats, the hypusine concentration in brain protein is higher in the first 2 weeks of postnatal life and then steadily decreases until adulthood (3). In this organ the amino acid is also present bound to γ-aminobutyric acid (GABA) (4).


Tritiated Water Picolinic Acid Polyamine Spermidine Deoxyhypusine Hydroxylase Polyamine Research 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. Abbruzzese
    • 1
  • V. Liguori
    • 1
  • M. H. Park
    • 2
  1. 1.Dipartimento di Biochimica e BiofisicaUniversita di NapoliItaly
  2. 2.National Institute of Dental ReserachNIHBethesdaUSA

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