Abstract
Because of gaps in our current scientific understanding of the cancer-causing process, human risk assessment for chemicals which have demonstrated carcinogenicity in rodents requires the use of a series of judgmental decisions on numerous unresolved scientific issues. Major assumptions are based on the necessity to extrapolate experimental results (1) across species from mice or rats to humans, (2) from the high-dose regions to which animals are exposed in the laboratory to the low-dose regions to which humans are exposed in the environment, and (3) across routes of administration.
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References
Andersen, M.E., H.J. Clewell, III, M.L. Gargas, F.A. Smith, and R.H. Reitz. (1987). Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87: 185–205.
Cohen, S.M., R.E. Greenfield, and L.B. Ellwein. (1983). Multistage carcinogenesis in the urinary bladder. Environ. Health Perspectives 49: 202–215.
Ellwein, L.B., and S.M. Cohen. (1986). Modeling of cellular dynamics in carcinogenesis risk assessment. Eppley Institute for Research on Cancer, University of Nebraska. ( Unpublished manuscript).
Ellwein, L.B. and S.M. Cohen. (1988). Cellular dynamics model of experimental bladder cancer: Analysis of the effect of sodium saccharin in the rat. Risk Analysis 8: 215–222.
Moolgavkar, S.H., N.E. Day, and R.G. Stevens. (1980). Two-stage model for carcinogenesis: Epidemiology of breast cancer in females. J. National Cancer Institute 65 (3): 559–569.
Moolgavkar, S.H. and A.G. Knudson, Jr. (1981)., Mutation and cancer: A model for human carcinogenesis. J. Natl. Cancer Inst. 66: 1037–1052.
Moolgavkar, S.H. (1986). Carcinogenesis modeling: From molecular biology to epidemiology. Ann. Rev. Public Health 7: 151–169.
Moolgavkar, S.H., A. Dewanji and D.J. Venzen. (1988). A stochastic two-stage model for cancer risk assessment I: The hazard function and the probability of tumor. Risk Analysis in press).
Paustenbach, D.J., M.E. Andersen, H.J. Clewell, III, and M.L. Gargas. (1988). A physiologically based pharmacokinetic model for inhaled carbon tetrachloride. Toxicol. Appl. Pharmacol. (in press).
Ramsey, J.C., and M.E. Andersen. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73: 159–175.
Reitz, R. H., R.J. Nolan, and A.M. Schumann. (1987). Organohalides. In Proceedings of the National Academy of Science Workshop on Pharmacokinetics, Safe Drinking Water Committee, Subcommittee on Pharmacokinetics, Board on Environmental Studies and Toxicology, National Research Council.
Reitz, R.H., J.N. McDougal, M.W. HimmelsteÃn, R.J. Nolan and A.M. Schumann. (1988). Physiologically-based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose and dose route extrapolations. Toxicol. Appl. Pharmacol. (in press).
Scherer, E., and P. Emmelot. (1976). Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. Cancer Res. 36: 2544–2554.
Thorslund, T.W., C.C. Brown and G. Charnley. (1987). Biologically motivated cancer risk models. Risk Analysis 7: 109–119.
Travis, C.C. (1987). Interspecies and Dose-Route Extrapolations. In Proceedings of the National Academy of Science Workshop on Pharmacokinetics, Safe Drinking Water Committee, Subcommittee on Pharmacokinetics, Board on Environmental Studies and Toxicology, National Research Council.
Ward, R.C., C.C. Travis, D.M. Hetrick, M.W. Andersen, and M.L. Gargas. (1988). Pharmacokinetics of tetrachloroethylene. Toxicol. Appl. Pharmacol. 93: 108–117.
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© 1989 Plenum Press, New York
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Travis, C.C. (1989). Research Needs for Biologically Based Risk Assessment. In: Travis, C.C. (eds) Biologically Based Methods for Cancer Risk Assessment. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5625-7_1
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DOI: https://doi.org/10.1007/978-1-4684-5625-7_1
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