Abstract
There is evidence showing that there is a significant variation in tumor-boron and blood-boron concentrations for individual patients. There also is a wide variation in the size and location of the tumor. This diversity creates a situation in which treatment must be carefully tailored to the specific needs of each patient. Patient treatment planning will require computer modeling of the various radiation transport and interaction processes expected to occur, coupled with a display of the results in easily interpretable form. Such an analytical evaluation will allow the radiation oncologist to select the beam configuration, specify the irradiation field and positions of local thermal neutron shields, establish the optimum time after boron administration to begin irradiation, and specify the duration of irradiation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bond, V. P., Varma, M. N., Son Dnaus, C. A., and Feinendegen, L. E., 1985, An alternative to absorbed dose, quality, and RBE at low exposures, Radiat. Res.,Suppl. 8, 104, S-52-S-57.
Deutsch, O. L. and Murray, B. W., 1975, Monte Carlo dosimetry calculation for boron neutron capture therapy in the treatment of brain tumors, Nucl. Technol., 26: 320.
Gabel, D., Fairchild, R.G., Larsson, B., Drescher, K., Rowe, W. R., 1983, The biological effect of the 10B(n,α)7 Li reaction and its simulation by Monte Carlo calculation, in: Proc. of the First International Symposium on Neutron Capture Therapy, Cambridge, MA, USA (R. G. Fairchild and G. L. Brownell, eds), BNL-51730, 128.
Gabel, D., Foster, S., and Fairchild, R. G., 1987, The I$nte Carlo simulation of the biological effect of the B(n,a) Li reaction in cells and tissue and its implication for boron neutron capture therapy, Radiat. Res. 111, 14.
Kellerer, A. M. and Rossi, H. H., 1972, The theory of dual radiation action, Current Topics in: Radiat. Res. Quarterly, 8: 85.
Kitao, K., 1975, A method forcalr9ulating the absorbed dose near interface from B(n,a) Li reaction, Radiat. Res., 61: 304.
Northcliffe, L. C. and Schilling, R. F., 1970, Range and stopping power tables for heavy ions, Nucl. Data Tables, A7: 233.
Rydin, R. A., Deutsch, O. L., and Murray, B. W., 1975, The effect of geometry on capillary wall dose for boron neutron capture therapy, Phys. Med. Biol., 21: 134.
Takeuchi, A., Nagata, T., Ohashi, F., Sasaki, N., Ushio, Y., and Hatanaka, H., 1985, Tolerance of canine brain to boron neutron capture therapy, Jpn. J. Vet. Sci., 47: 859.
Ziegler, J. F., Biersack, J. P., and Littmark, U., 1985, “The Stopping and Range of Ions in Solids”, Pergammon Press, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Wheeler, F.J., Griebenow, M.L., Wessol, D.E., Nigg, D.W., Anderl, R.A. (1989). A Stochastic Model for High-Let Response for Boron Neutron Capture Therapy (BNCT). In: Fairchild, R.G., Bond, V.P., Woodhead, A.D., Vivirito, K. (eds) Clinical Aspects of Neutron Capture Therapy. Basic Life Sciences, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5622-6_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5622-6_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5624-0
Online ISBN: 978-1-4684-5622-6
eBook Packages: Springer Book Archive