Clinical Aspects of Neutron Capture Therapy

  • Ralph G. Fairchild
  • Victor P. Bond
  • Avril D. Woodhead
  • Katherine Vivirito

Part of the Basic Life Sciences book series (BLSC, volume 50)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Dose Rate and Therapeutic Gain

    1. R. G. Fairchild
      Pages 1-7
  3. Swine Skin: A Model to Evaluate Dose Recovery from Different Radiations

  4. Neutron Capture Therapy in Support of Other Radiation Treatment

  5. Research on Neutron Capture Therapy in the USSR

  6. BNCT Project in Czechoslovakia

    1. J. Burian, I. Janku, J. Kvitek, V. Mares, Z. Prouza, F. Spurny et al.
      Pages 39-48
  7. Proposed Clinical Trial Studying the Pharmacokinetics of B.S.H.

    1. William Frederic James Harkness
      Pages 49-51
  8. Fractionation in Boron Neutron Capture Therapy

    1. K. R. Durrant, J. Hopewell
      Pages 53-61
  9. Dose Fractionation in Neutron Capture Therapy for Malignant Melanoma

  10. Thermal Neutron Capture Therapy: The Japanese-Australian Clinical Trial for Malignant Melanoma

    1. B. J. Allen, A. S. Coates, W. H. McCarthy, H. Mameghan, Y. Mishima, M. Ichihashi
      Pages 69-73
  11. BNCT and Dose Fractionation

    1. John L. Russell Jr.
      Pages 75-79
  12. Some Thoughts on Tolerance, dose, and Fractionation in Boron Neutron Capture Therapy

    1. Reinhard Gahbauer, Joseph Goodman, Thomas Blue
      Pages 81-85
  13. Delayed Effects of Neutron Irradiation on Central Nervous System Microvasculature in the Rat

    1. J. H. Goodman, J. M. McGregor, N. R. Clendenon, W. A. Gordon, A. J. Yates, R. A. Gahbauer et al.
      Pages 87-93
  14. Pre-Clinical Studies on Boron Neutron Capture Therapy

    1. Rolf F. Barth, Albert H. Soloway, Fazlul Alam, Nancy R. Clendenon, Thomas E. Blue, Naoki Mafune et al.
      Pages 95-105
  15. Boron Compounds for Neutron Capture Therapy

    1. F. Alam, A. H. Soloway, B. V. Bapat, R. F. Barth, D. M. Adams
      Pages 107-111
  16. Fractionation Considerations for Boron Neutron Capture Therapy: The Perspective of a Clinician

  17. Vascular Factors Affecting Drug Delivery to Brain Tumors

    1. George Tyson, Joseph Fenstermacher, Raphael Davis
      Pages 115-120
  18. Clinical Considerations in the Use of Thermal and Epithermal Neutron Beams for Neutron Capture Therapy

    1. Robert G. A. Zamenhof, Hywel Madoc-Jones, Otto K. Harling, John A. Bernard Jr.
      Pages 121-134
  19. A Proposed Protocol for Clinical Trials of Boron Neutron Capture Therapy in Glioblastoma Multiforme

    1. Ronald V. Dorn III, John H. Spickard, Merle L. Griebenow
      Pages 135-144
  20. The Effect of Ionizing Radiation on the Blood-Brain-Barrier (BBB): Considerations for the Application of Boron Neutron Capture Therapy (BNCT) of Brain Tumors

  21. Computerized Axial Tomographic and Magnetic Resonance Imaging Scan Follow-up of Two Patients after Boron Neutron Capture Therapy for Glioblastoma Multiforme

  22. A Stochastic Model for High-Let Response for Boron Neutron Capture Therapy (BNCT)

    1. Floyd J. Wheeler, Merle L. Griebenow, Daniel E. Wessol, David W. Nigg, Robert A. Anderl
      Pages 165-178
  23. Distributions of Sulfhydryl Borane Monomer and Dimer in Rodents and Monomer in Humans: Boron Neutron Capture Therapy of Melanoma and Glioma in Boronated Rodents

    1. D. N. Slatkin, D. D. Joel, R. G. Fairchild, P. L. Micca, M. M. Nawrocky, B. H. Laster et al.
      Pages 179-191
  24. A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors

    1. S. B. Kahl, D. D. Joel, G. C. Finkel, P. L. Micca, M. M. Nawrocky, J. A. Coderre et al.
      Pages 193-203
  25. Distribution of a Boronated Porphyrin in Murine Tumors

    1. S. B. Kahl, B. H. Laster, M.-S. Koo, L. S. Warkentien, R. G. Fairchild
      Pages 205-212
  26. Survival Assays with a Boronated Porphyrin as Measured with Hamster V-79 Cells in Culture

    1. B. H. Laster, S. B. Kahl, E. A. Popenoe, C. Gordon, J. Kalef-Ezra, R. G. Fairchild
      Pages 213-218
  27. Neutron Capture Therapy for Melanoma

    1. Jeffrey A. Coderre, John D. Glass, Peggy Micca, Ralph G. Fairchild
      Pages 219-232
  28. Tumor-Seeking Compounds for Boron Neutron Capture Therapy: Synthesis and Biodistribution

  29. Boron-11 Magnetic Resonance Imaging and Spectroscopy; Tools for Investigating Pharmacokinetics for Boron Neutron Capture Therapy

  30. Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma: From Basic Studies to First Clinical Treatment

    1. Yutaka Mishima, Masamitsu Ichihashi, Susumu Hatta, Chihiro Honda, Akihiro Sasase, Keizo Yamamura et al.
      Pages 251-260
  31. Workshop Summary of Moderators’ Reports

    1. Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito
      Pages 261-262
  32. Moderators’ Report and Discussions

    1. Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito
      Pages 263-276
  33. Working Group on Optimization of Radiation Dose Delivery

    1. Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito
      Pages 277-297
  34. Contributed Papers

    1. H. Conde, E. Grusell, B. Larsson, E. Ramstrom, T. Ronnqvist, H. Sornsuntisook et al.
      Pages 319-323
    2. Paul G. Marshall, Marilyn E. Miller, Stanley Grand, Peggy L. Micca, Daniel N. Slatkin
      Pages 333-351
  35. Back Matter
    Pages 353-370

About this book


Since Locher first suggested Boron Neutron Capture Therapy (BNCT) in 1936, this theoretically ideal system has intrigued investigators. Unfortunately, the first clinical trials between 1951-1961 were not successful. However, they served to implant firmly the seed of BNCT, the growth of which has been carefully nurtured at a number of locations world-wide. This fact is attested to by the ongoing clinical trials in Japan as well as by the presence of researchers from active groups in the ten countries represented at this Workshop. In 1983 and 1985, the first and second international biannual symposia on BNCT were held, in response to a resurgence of interest in this field. In 1986, the DOE sponsored a workshop on NCT, in large part directed toward evaluating the national effort and the various neutron sources available within the United States. It now seems likely, because of various factors including improved neutron beams and boron delivery systems which have made the modality more attractive, that clinical trials will be initiated in the United States within the next few years. This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project. Our purpose is to facilitate our endeavor to incorporate the best procedures and techniques in the upcoming clinical trials.


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Editors and affiliations

  • Ralph G. Fairchild
    • 1
  • Victor P. Bond
    • 1
  • Avril D. Woodhead
    • 1
  • Katherine Vivirito
    • 1
  1. 1.Brookhaven National LaboratoryUptonUSA

Bibliographic information