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A Proposed Protocol for Clinical Trials of Boron Neutron Capture Therapy in Glioblastoma Multiforme

  • Ronald V. DornIII
  • John H. Spickard
  • Merle L. Griebenow
Part of the Basic Life Sciences book series (BLSC, volume 50)

Abstract

Neutron Capture Therapy (NCT) was suggested in theory as a treatment for malignant tumors some 50 years ago. Since then, considerable data have accumulated on the mechanisms of action and possible application of this technique. This paper outlines a protocol for a controlled study of the use of Boron Neutron Capture Therapy (BNCT) for the treatment of Glioblastoma Multiforme (GM). The protocol is one component of a comprehensive national BNCT research program at the Idaho National Engineering Laboratory (INEL) directed towards validating (or invalidating) NCT as a treatment for human malignancies.

Keywords

Glioblastoma Multiforrne Karnofsky Performance Status Radiation Therapy Oncology Group Boron Neutron Capture Therapy Relative Biologic Effectiveness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. Kornbulith, P. L., et al., 1985, Neoplasms of the Central Nervous System, in Cancer: Principles and Practice of Oncology, DeVita, V. T., Hellman, S., Rosenberg, S. A., editors, 1985, Lippincott, Philadelphia.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Ronald V. DornIII
    • 1
    • 2
  • John H. Spickard
    • 1
    • 2
  • Merle L. Griebenow
    • 1
    • 2
  1. 1.Idaho National Engineering LaboratoryEG&G Idaho, Inc.Idaho FallsUSA
  2. 2.Mountain States Tumor InstituteBoiseUSA

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