A Proposed Protocol for Clinical Trials of Boron Neutron Capture Therapy in Glioblastoma Multiforme
Neutron Capture Therapy (NCT) was suggested in theory as a treatment for malignant tumors some 50 years ago. Since then, considerable data have accumulated on the mechanisms of action and possible application of this technique. This paper outlines a protocol for a controlled study of the use of Boron Neutron Capture Therapy (BNCT) for the treatment of Glioblastoma Multiforme (GM). The protocol is one component of a comprehensive national BNCT research program at the Idaho National Engineering Laboratory (INEL) directed towards validating (or invalidating) NCT as a treatment for human malignancies.
KeywordsGlioblastoma Multiforrne Karnofsky Performance Status Radiation Therapy Oncology Group Boron Neutron Capture Therapy Relative Biologic Effectiveness
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