Morphological Sequelae of Anterior Segment Hydrogen Peroxide in Young and Adult Rabbits with or Without 3-Aminotriazole Treatment
Both intravenous and oral 3-amino-triazole (3AT) are known to reduce catalase activity in ocular tissues;1 a single intravenous injection of 3AT depresses catalase levels in iris, ciliary processes, retina, corneal endothelium and epithelium and lens capsule epithelium within 1 hour and is of several days duration. After intravenous 3AT we have shown that the t½ of hydrogen peroxide clearance for rabbit anterior chamber is extended, dependent upon the dose of administered 3AT. This provided affirmation of the role of catalase in modulating the disappearance of anterior chamber hydrogen peroxide. No morphological studies have been made, however, of anterior segment tissues, save the lens,2 after 3AT treatment. The present studies were designed to fill this void.
KeywordsCatalase Activity Anterior Chamber Ocular Tissue Corneal Endothelium Adult Rabbit
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