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Morphological Sequelae of Anterior Segment Hydrogen Peroxide in Young and Adult Rabbits with or Without 3-Aminotriazole Treatment

  • Anastasios Costarides
  • David Birnbaum
  • Stephen Csukas
  • Elizabeth Forbes
  • Keith Green
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Both intravenous and oral 3-amino-triazole (3AT) are known to reduce catalase activity in ocular tissues;1 a single intravenous injection of 3AT depresses catalase levels in iris, ciliary processes, retina, corneal endothelium and epithelium and lens capsule epithelium within 1 hour and is of several days duration. After intravenous 3AT we have shown that the t½ of hydrogen peroxide clearance for rabbit anterior chamber is extended, dependent upon the dose of administered 3AT. This provided affirmation of the role of catalase in modulating the disappearance of anterior chamber hydrogen peroxide. No morphological studies have been made, however, of anterior segment tissues, save the lens,2 after 3AT treatment. The present studies were designed to fill this void.

Keywords

Catalase Activity Anterior Chamber Ocular Tissue Corneal Endothelium Adult Rabbit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Anastasios Costarides
    • 1
    • 2
  • David Birnbaum
    • 1
  • Stephen Csukas
    • 1
    • 2
  • Elizabeth Forbes
    • 1
  • Keith Green
    • 1
    • 2
  1. 1.Department of OphthalmologyMedical College of GeorgiaAugustaUSA
  2. 2.Department of Physiology and EndocrinologyMedical College of GeorgiaAugustaUSA

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