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Morphological Sequelae of Anterior Segment Hydrogen Peroxide in Young and Adult Rabbits with or Without 3-Aminotriazole Treatment

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Oxygen Radicals in Biology and Medicine

Part of the book series: Basic Life Sciences ((BLSC,volume 49))

Abstract

Both intravenous and oral 3-amino-triazole (3AT) are known to reduce catalase activity in ocular tissues;1 a single intravenous injection of 3AT depresses catalase levels in iris, ciliary processes, retina, corneal endothelium and epithelium and lens capsule epithelium within 1 hour and is of several days duration. After intravenous 3AT we have shown that the t½ of hydrogen peroxide clearance for rabbit anterior chamber is extended, dependent upon the dose of administered 3AT. This provided affirmation of the role of catalase in modulating the disappearance of anterior chamber hydrogen peroxide. No morphological studies have been made, however, of anterior segment tissues, save the lens,2 after 3AT treatment. The present studies were designed to fill this void.

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References

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia, 30912-3400, USA

    Anastasios Costarides, David Birnbaum, Stephen Csukas, Elizabeth Forbes & Keith Green

  2. Department of Physiology and Endocrinology, Medical College of Georgia, Augusta, Georgia, 30912-3400, USA

    Anastasios Costarides, Stephen Csukas & Keith Green

Authors
  1. Anastasios Costarides
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  2. David Birnbaum
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  3. Stephen Csukas
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  4. Elizabeth Forbes
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  5. Keith Green
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. International Life Sciences Institute, Washington, D.C., USA

    Karen A. Taylor

  3. Univesity of California, San Diego, La Jolla, California, USA

    John F. Ward

  4. Max-Planck-Institut für Strahlenchemie, Mülheim a.d. Ruhr, Federal Republic of Germany

    Clemens von Sonntag

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© 1988 Plenum Press, New York

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Costarides, A., Birnbaum, D., Csukas, S., Forbes, E., Green, K. (1988). Morphological Sequelae of Anterior Segment Hydrogen Peroxide in Young and Adult Rabbits with or Without 3-Aminotriazole Treatment. In: Simic, M.G., Taylor, K.A., Ward, J.F., von Sonntag, C. (eds) Oxygen Radicals in Biology and Medicine. Basic Life Sciences, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5568-7_171

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  • DOI: https://doi.org/10.1007/978-1-4684-5568-7_171

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5570-0

  • Online ISBN: 978-1-4684-5568-7

  • eBook Packages: Springer Book Archive

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