Oxygen Radicals in Biology and Medicine

  • Michael G. Simic
  • Karen A. Taylor
  • John F. Ward
  • Clemens von Sonntag

Part of the Basic Life Sciences book series (BLSC, volume 49)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Introduction

    1. Michael G. Simic, Karen A. Taylor
      Pages 1-10
  3. Kinetics and Mechanisms

    1. Aryeh A. Frimer
      Pages 29-38
    2. C. von Sonntag
      Pages 47-54
    3. S. Das, O. J. Mieden, X.-M. Pan, M. Repas, M. N. Schuchmann, H.-P. Schuchraann et al.
      Pages 55-58
    4. J. C. Scaiano
      Pages 59-66
    5. Klaus-Dieter Asmus, Manohar Lal, Jörg Mönig, Christian Schöneich
      Pages 67-73
    6. Kathryn T. Knecht, Carolyn Mottley, Ronald P. Mason
      Pages 75-79
    7. Slobodan V. Jovanovic, Michael G. Simic
      Pages 115-122
  4. Generation of Oxy Radicals

    1. Benon H. J. Bielski
      Pages 123-130
    2. E. R. Stadtman, B. S. Berlett
      Pages 131-136
    3. Steven D. Aust
      Pages 137-144
    4. William F. Hodnick, B. Kalyanaraman, Chris A. Pritsos, Ronald S. Pardini
      Pages 149-152
    5. Joseph M. Rifkind, Lu Zhang, Jane M. Heim, Abraham Levy
      Pages 157-162
  5. Detection and Measurement

    1. S. Matsushita, J. Terao, K. Yamada, S. S. Shibata
      Pages 163-174
    2. Hartmut Frank, Manfred Wiegand, Dietmar Thiel
      Pages 175-178
    3. F. J. G. M. van Kuijk, D. W. Thomas, R. J. Stephens, E. A. Dratz
      Pages 179-183
    4. Teruo Miyazawa, Keiichi Yasuda, Kenshiro Fujimoto, Takashi Kaneda
      Pages 191-194
    5. H. H. Draper, M. Hadley
      Pages 199-202
  6. Chemiluminescence

    1. J. T. Warren, A. H. Esa, G. R. Pettit, W. S. May
      Pages 223-227
    2. Ambler Thompson, W. H. Biggley, Howard H. Seliger
      Pages 229-232
    3. T. Metsä-Ketelä, A. Montfoort, T. Kunnas
      Pages 233-238
    4. Julio F. Turrens, Cecilia Giulivi, Claudia Pinus, Emilio Roldan, Carla Lavagno, Alberto Boveris
      Pages 239-242
    5. Hiroshi Yasuda, Masayuki Miki, Yoshito Takenaka, Hiroshi Tamai, Makoto Mino
      Pages 249-254
    6. Johnathan L. Kiel, David M. Simmons, David N. Erwin
      Pages 261-264
  7. Free Radicals and Oxygen Species in Lipids

    1. Edwin N. Frankel
      Pages 265-282
    2. Robert J. Stephens, Dalbir S. Negi, Sarah M. Short, Frederik J. G. M. van Kuijk, Edward A. Dratz, David W. Thomas
      Pages 283-289
    3. Stella Harel, Joseph Shagalovich, Bella Hazan, Joseph Kanner
      Pages 301-306
    4. Leland L. Smith, Krzysztof Jaworski
      Pages 313-317
    5. Motoko Oarada, Teruo Miyazawa, Kenshiro Fujimoto, Takashi Kaneda, Emiko Ito, Kiyoshi Terao
      Pages 327-330

About this book


This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.


Oxidation antioxidant biology chemistry pharmacology

Editors and affiliations

  • Michael G. Simic
    • 1
  • Karen A. Taylor
    • 2
  • John F. Ward
    • 3
  • Clemens von Sonntag
    • 4
  1. 1.National Bureau of StandardsGaithersburgUSA
  2. 2.International Life Sciences InstituteUSA
  3. 3.Univesity of California, San DiegoLa JollaUSA
  4. 4.Max-Planck-Institut für StrahlenchemieMülheim a.d. RuhrFederal Republic of Germany

Bibliographic information