Oxygen Radicals in Biology and Medicine

  • Michael G. Simic
  • Karen A. Taylor
  • John F. Ward
  • Clemens von Sonntag

Part of the Basic Life Sciences book series (BLSC, volume 49)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Introduction

    1. Michael G. Simic, Karen A. Taylor
      Pages 1-10
  3. Kinetics and Mechanisms

    1. Aryeh A. Frimer
      Pages 29-38
    2. C. von Sonntag
      Pages 47-54
    3. S. Das, O. J. Mieden, X.-M. Pan, M. Repas, M. N. Schuchmann, H.-P. Schuchraann et al.
      Pages 55-58
    4. J. C. Scaiano
      Pages 59-66
    5. Klaus-Dieter Asmus, Manohar Lal, Jörg Mönig, Christian Schöneich
      Pages 67-73
    6. Kathryn T. Knecht, Carolyn Mottley, Ronald P. Mason
      Pages 75-79
    7. Slobodan V. Jovanovic, Michael G. Simic
      Pages 115-122
  4. Generation of Oxy Radicals

    1. Benon H. J. Bielski
      Pages 123-130
    2. E. R. Stadtman, B. S. Berlett
      Pages 131-136
    3. Steven D. Aust
      Pages 137-144

About this book


This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.


Oxidation antioxidant biology chemistry pharmacology

Editors and affiliations

  • Michael G. Simic
    • 1
  • Karen A. Taylor
    • 2
  • John F. Ward
    • 3
  • Clemens von Sonntag
    • 4
  1. 1.National Bureau of StandardsGaithersburgUSA
  2. 2.International Life Sciences InstituteUSA
  3. 3.Univesity of California, San DiegoLa JollaUSA
  4. 4.Max-Planck-Institut für StrahlenchemieMülheim a.d. RuhrFederal Republic of Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5568-7
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5570-0
  • Online ISBN 978-1-4684-5568-7
  • About this book