Abstract
While it is known that oxygen intermediates, i.e., the superoxide radical anion, hydrogen peroxide, and the hydroxyl radical are toxic1–3, their role in pathological processes in the central nervous system (CNS) is not clear. To understand how these reactive oxygen metabolites are involved, two issues must be addressed. First, are there endogenous sources of oxygen intermediates in the CNS? Second, can oxygen intermediates produce functional neuronal changes?
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References
R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, and W. O. Fenn, Oxygen poisoning and x-irradiation: A mechanism in common, Science 119:623 (1954).
D. L. Gilbert, ed., “Oxygen and Living Processes: An Interdisciplinary Approach,” Springer-Verlag, New York (1981).
B. Halliwell and J. Gutteridge, Oxygen radicals and the nervous system, Trends in Neurosci. 8:22 (1985).
B. Babior, R. Kipnes, and J. Curnutte, Biological defense mechanisms: The production by leucocytes of superoxide, a potential bactericidal agent, J. Clin. Invest. 52:741 (1973).
W. Lo and L. Betz, Oxygen free radical reduction of brain capillary rubidium uptake, J. Neurochem. 46:394 (1986).
D. E. Parks, Reperfusion injury in ischemic tissues: Role of oxygen derived free radicals, in: “Oxygen: An Indepth Study of Its Pathophysiology,” S. Gottlieb, I. Longmuir and J. Totter, eds., Undersea Medical Soc., Bethesda, MD (1983).
M. S. Patole, A. Swaroop, and T. Ramasarma, Generation of H2O2 in brain mitochondria, J. Neurochem. 47:1 (1986).
L. Betz, Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries, J. Neurochem. 44:574 (1985).
H. Kontos, Oxygen radicals from arachidonate metabolism in abnormal vascular responses, Am. Rev. Respir. Dis. 136:474 (1987).
H. A. Kontos and E. P. Wei, Superoxide production in experimental brain injury, J. Neurosurg. 64:803, 1986.
D. Giulian and T. Baker, Characterization of ameboid microglia isolated from developing mammalian brain, J. Neurosci. 6:2163 (1986).
E. Ling, C. Kaur, and W. Wong, Light and electron microscopic demonstration of non-specific esterase in amoeboid microglial cells in the corpus callosum in postnatal rats: A cytochemical link to monocytes, J. Anat. 135:385 (1982).
V. Perry, D. Hume, and S. Gordon, Immunocytochemical localization of macrophages and microglia in the adult and developing mouse brain, Neurosci. 15:313 (1985).
C. Colton and D. Gilbert, Production of superoxide anions by a CNS macrophage, the microglia, FEBS Lttrs. 223:284 (1987).
R. Johnston, Jr., Measurement of O2 - secretion by monocytes and macrophages, Methods Enzymol. 105:365 (1984).
R. Fox, Prevention of granulocyte mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylurea, J. Clin. Invest. 74:1456 (1984).
W. Bannister, Superoxide dismutase and disease, in: “The Biology and Chemistry of Active Oxygen,” J. Bannister and W. Bannister, eds., Elsevier, New York (1984).
J. Crapo, B. Freeman, B. Barry, J. Turrens, and S. Young, Mechanisms of hyperoxic injury to the pulmonary microcirculation, Physiologist, 26:170 (1983).
R. Del Maestro, An approach to free radicals in medicine and biology, Acta Physiol. Scand. Suppl. 492:153 (1980).
C. Colton, J. Colton, and D. Gilbert, Changes in synaptic transmission produced by hydrogen peroxide, J. Free Rad. Biol. Med. 2:141 (1986).
T. Pellmar, Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro, Brain Res. 364:377 (1986).
C. Colton, L. Fagni, and D. Gilbert, The action of an oxygen intermediate, H2O2 on synaptic modulation in the hippocampus, in preparation.
L. Voronin, Long term potentiation in the hippocampus, Neurosci. 10:1051 (1983).
T. Brannan, H. Maker, and I. Raes, Regional distribution of catalase in the adult rat brain, J. Neurochem. 36:307 (1981).
P. H. Chan, M. Yurko, and R. Fishman, Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices, J. Neurochem. 38:525 (1982).
R. Fried, Superoxide dismutase activity in the nervous system, J. Neurosci. Res. 4:435 (1979).
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© 1988 Plenum Press, New York
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Colton, C.A., Gilbert, D.L. (1988). An Endogenous Source of the Superoxide Anion in the Central Nervous System. In: Simic, M.G., Taylor, K.A., Ward, J.F., von Sonntag, C. (eds) Oxygen Radicals in Biology and Medicine. Basic Life Sciences, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5568-7_165
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DOI: https://doi.org/10.1007/978-1-4684-5568-7_165
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