An Endogenous Source of the Superoxide Anion in the Central Nervous System
While it is known that oxygen intermediates, i.e., the superoxide radical anion, hydrogen peroxide, and the hydroxyl radical are toxic1–3, their role in pathological processes in the central nervous system (CNS) is not clear. To understand how these reactive oxygen metabolites are involved, two issues must be addressed. First, are there endogenous sources of oxygen intermediates in the CNS? Second, can oxygen intermediates produce functional neuronal changes?
KeywordsXanthine Oxidase Platelet Activate Factor Long Term Potentiation Phorbol Myristate Acetate Phorbol Myristate Acetate
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