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The Use of Oxygen Free Radical Scavengers in the Rat Peritonitis Model

  • Whitney M. Limm
  • Susan N. Ishikawa
  • Thomas Grover
  • J. Judson McNamara
  • Lawrence H. Piette
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

In the 1960s, Davis and Yull noted synergistic effect on mortality between E. coli and red blood cells (RBCs) instilled into the peritoneum of rats.1 Specifically, when E. coli at a level of 109 bacteria/cc and hemoglobin (Hb) in a concentration of 4 gm% were injected intraperitone-ally, the 24-hour mortality rate was 90%. When E. coli or hemoglobin was injected separately, there was minimal mortality. This lethal synergistic action has been repeatedly demonstrated as investigators have noted mortality rates of 70 to 90% with this combination.2–5 However, except for the implication of iron as the critical agent,6 little progress has been made in elucidating the adjuvant effect of hemoglobin. Furthermore, no effective treatment has been found.

Keywords

Fenton Reaction Abdominal Injury Adjuvant Effect Adjuvant Action Oxygen Free Radical Scavenger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Whitney M. Limm
    • 1
  • Susan N. Ishikawa
    • 1
  • Thomas Grover
    • 2
  • J. Judson McNamara
    • 1
  • Lawrence H. Piette
    • 2
  1. 1.Cardiovascular Research LaboratoryQueen’s Medical CenterHonoluluUSA
  2. 2.Department of Chemistry and BiochemistryUtah State UniversityLoganUSA

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