Summary
An ischaemic infarct was produced in primates by applying a clip to the right middle cerebral artery. Enzyme histochemical data are presented, documenting the development of a focal ischaemic brain lesion. The relatively slow demarcation of the ischaemic brain infarct appears to be correlated with the efficiency of the collateral blood supply. The extent of the collateral blood supply is documented by morphometric data on the brain capillaries. It was evident that effective intervention in the infarction process with a view to limiting the extent of an ischaemic brain lesion is possible only at an early stage. A reduction of blood viscosity by bloodletting and haemodilution is the most important measure to be taken in the first few hours after a stroke. The second important step in the treatment of acute stroke is inhibition of blood platelet aggregation to arrest the thrombotic process and avoid complete occlusion of the artery, or in the case of an embolism to limit the extent of the infarct.
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© 1988 Plenum Press, New York
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Meier-Ruge, W., Theodore, D., Abraham, J. (1988). Pathology of Ischaemic Brain Damage — Implications for Therapy. In: Somjen, G. (eds) Mechanisms of Cerebral Hypoxia and Stroke. Advances in Behavioral Biology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5562-5_9
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DOI: https://doi.org/10.1007/978-1-4684-5562-5_9
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