Double blind study of the influence of co-dergocrine on platelet parameters in healthy volunteers

Summary

In 20 healthy volunteers double-blind randomized study was done to examine the effect of codergocrine (Hydergin) on platelet function. All the volunteers were pretreated with 3×1 placebo for 1 week, followed by the randomized study in which 10 volunteers each received drug or placebo for 6 weeks. Various platelet function parameters, such as the peripheral platelet count, plasma thromboxane B₂, platelet sensitivity to the antigaggregatory prostaglandins PGI₂, PGE₁ and PGD₂, ADP-in-duced aggregation, collagen-induced aggregation, the WU-test, the platelet proteins platelet factor 4 and β-thromboglobulin, malondialdehyde, circulating endothelial cells and the intracellular c-AMP level in platelets were examined. Treatment with co-dergocrine decreased platelet activity to a significant extent, as shown by a number of platelet function parameters, such as thromboxane B₂, WU-test, β-thromboglobulin, platelet factor 4, malondialdehyde and ADP-induced aggregation. The findings suggest that co-dergocrine might be able to decrease platelet activity and improve interaction with the walls of to a blood-vessel significant degree.