Abstract
Radioimmunoscintigraphy, RIS, is currently undertaken with, by nuclear medicine standards, a poor radiopharmaceutical since usually less than one per cent of the administered activity is taken up by the tumor. This may be compared with over 70% of the administered Tc-99m labeled tin colloid taken up by the liver during a liver scan. The requirement is to detect small tumor recurrences, firstly since large tumors are either clinically or radiologically apparent so the extra test using RIS does not contribute to clinical management, and secondly since radioimmunotherapy appears efficacious only in patients whose tumor recurrences are under 2 cm in size (see Kalofonos and Epenetos, This book, Part VIII). Some of the physical problems that arise when attempting to image small tumors have been outlined by Britton and Granowska (This book, Part II). The prime importance of a good signal is stressed so the Poisson noise inherent in the signal is reduced. However, for a given signal, tissue and blood background activity due to the radiopharmaceutical contributes a further source of noise. While reduction of this noise in the tumor environment may be obtained by more rapid clearance of unbound antibody through the use of F(ab′)2 fragments or second antibody clearance techniques, and/or by the use of single photon emission tomography, these approaches also have inherent problems and sources of error. An alternative is to reduce the effect of tissue background activity by some form of subtraction technique.
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Kaplan, E., Ben-Porath, M., Pink, S., Clayton, G.D., and Jacobson, B., 1966, Elimination of liver interference from the selenomethionine pancreas scan. J. Nuc. Med. 7: 807.
Goldenberg, D.M., Kim, E.E., Deland, F.H., Bennett, S., and Primus, F.J., 1980, Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res. 40: 2984.
Granowska, M., Britton, K.E., and Shepherd, J., 1983, The detection of ovarian cancer using 123-I monoclonal antibody. Radiobiol. Radiother. 25: 153.
Granowska, M., Shepherd, J., Britton, K.E., Ward, B., Mather, S., Taylor-Papadimitriou, J., Epenetos, A.A., Carroll, M.J., Nimmon, C.C., Hawkins, L.A., Flatman, W.D., Home, T., and Bodmer, W.R., 1984, Ovarian cancer: Diagnosis using 123-I monoclonal antibody in comparison with surgical findings. Nucl. Med. Commun. 5: 485.
Granowska, M., Pring, W.D., Nimmon, C.C., Shepherd, J., Ward, B., Singh, P., Mather, S., Bomanji, J., Slevin, M.L., and Britton, K.E., 1985, Kinetic analysis of radioimmunoscintigraphy, RIS, using probability mapping: comparison with multiple biopsy findings in ovarian cancer. Proc. Europ. Nucl. Med. Cong. London 1985. Ear. J. Nuc. Med. 11: A7.
Granowska, M., Britton, K.E., Shepherd, J.H., Nimmon, C.C., Mather, S., Ward, B., Osborne, R.J., and Slevin, M.L., 1986, A prospective study of 123-I labelled monoclonal antibody imaging in ovarian cancer. J. Clin. Onc. 4:730.
Green, A.J., Begent, R.H.J., Keep, P.A., and Bagshawe, K.E., 1984, Analysis of radioimmunodetection of tumours by the subtraction technique. J. Nuc. Med., 25: 96.
Nimmon, C.C., Carroll, M.J., Flatman, W.D., Marsden, P., Granowska, M., Horne, T., and Britton, K.E., 1984, Spatial probability mapping of temporal change: application to gamma camera quality control and immunoscintigraphy. Nacl. Med. Commun. 5: 231.
Ott, R.J., Grey, L.J., Zivanovic, M.A., Flower, M.A., Trott, N.G., Moshakis, V., Coombes, R.C., Neville, A.M., Ormerod, M.G., and Westwood, J.H., 1983, The limitations of the dual radionuclide subtraction technique for the external detection of tumours by radioiodine labelled antibodies. Brit. J. Radiol. 56: 101.
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© 1988 Springer Science+Business Media New York
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Granowska, M., Britton, K.E., Crowther, M., Nimmon, C.C., Slevin, M.L., Shepherd, J. (1988). Kinetic Analysis with Probability Mapping in Radioimmunoscintigraphy. In: Srivastava, S.C. (eds) Radiolabeled Monoclonal Antibodies for Imaging and Therapy. NATO ASI Series, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5538-0_22
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DOI: https://doi.org/10.1007/978-1-4684-5538-0_22
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