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  • Conference proceedings
  • © 1988

Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Editors:

  1. Suresh C. Srivastava

    1. Brookhaven National Laboratory, Upton, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 152)

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Table of contents (53 papers)

  1. Front Matter

    Pages i-xiv
    PDF

  2. General: Monoclonal Antibody Production, Selection, and Characterization

    1. Front Matter

      Pages 1-1
      PDF

    2. Immunochemistry of Hybridomas

      • Peter D. Gorevic
      Pages 3-21
      PDF

    3. Characterization and Selection Criteria of Monoclonal Antibodies for Tumor Imaging Studies

      • A. A. Noujaim, B. M. Longenecker, M. R. Suresh, C. J. Turner, T. R. Sykes, G. D. MacLean
      Pages 23-38
      PDF

    4. Tumor Markers and Their Relevance in the Design of Radioimmunoimaging Experiments

      • A. A. Noujaim, B. M. Longenecker, M. R. Suresh, G. D. MacLean, C. J. Turner, T. R. Sykes
      Pages 39-50
      PDF
    5. PDF

    6. Selection and Utilization of Monoclonal Antibody Defined Melanoma Associated Antigens for Immunoscintigraphy in Patients with Melanoma

      • S. Ferrone, M. Temponi, D. Gargiulo, G. A. Scassellati, R. Cavaliere, P. G. Natali
      Pages 55-73
      PDF

    7. Development and Characterization of Human Monoclonal Antibodies and Their Application in the Radioimmunodetection of Colon Carcinoma

      • Richard P. McCabe, Leona C. Peters, Martin V. Haspel, Nicholas Pomato, Jorge A. Carrasquillo
      Pages 75-94
      PDF

    8. Progress in Diagnostic Immunoscintigraphy and First Approach to Radioimmunotherapy of Colon Carcinoma

      • Jean-Pierre Mach, Franz Buchegger, Angelika Bischof-Delaloye, Sven Curchod, Ariane Studer, Pelham Douglas et al.
      Pages 95-110
      PDF

    9. The Design of a Radiolabeled Monoclonal Antibody for Radioimmunodiagnosis and Radioimmunotherapy

      • S. J. DeNardo, G. L. DeNardo, S. V. Deshpande, G. P. Adams, D. J. Macey, S. L. Mills et al.
      Pages 111-122
      PDF

    10. Immunohistochemistry and Correlation with Plasma Levels of CA 19-9 and CEA in Gastrointestinal Tumors

      • M. Lorenz, R. P. Baum, G. Herrmann, R. Inglis, M. Schulz
      Pages 123-128
      PDF

    11. Optimization of Mouse IgG Fragmentation Technique in the Selection of Monoclonal Antibodies for Myocardial Infarct Imaging

      • Catherine Larue, Corinne Chateigner, Patrick Gautier, Jacques Planchenault, Jocelyne Leger
      Pages 129-137
      PDF

    12. Sensitivity and Efficacy Indices for Oncologic Data Reporting

      • Alexander Gottschalk, Eugene Cornelius, Paul B. Hoffer
      Pages 139-145
      PDF

  3. Selection Criteria for Imaging and Therapy and the Production of Radionuclides

    1. Front Matter

      Pages 147-147
      PDF

    2. Production and Use of Prospective Radionuclides for Radioimmunotherapy

      • Leonard F. Mausner, Rita F. Straub, Suresh C. Srivastava
      Pages 149-163
      PDF

    3. Criteria for the Selection of Nuclides for Radioimmunotherapy

      • S. James Adelstein, Amin I. Kassis
      Pages 165-176
      PDF

    4. Experience with Iodine-123 Labeled Antibodies

      • Keith Britton, Marie Granowska
      Pages 177-191
      PDF

  4. Radiohalogenation and Radiometal Labeling of Monoclonal Antibodies

    1. Front Matter

      Pages 193-193
      PDF

    2. Radiohalogenation of Antibodies: Chemical Aspects

      • Michael R. Zalutsky
      Pages 195-213
      PDF

    3. Radiohalogenation of Monoclonal Antibodies: Experiences with Radioiodination of Monoclonal Antibodies for Radioimmunotherapy

      • James C. Reynolds, Patrick Maloney, Mark Rotman, Richard Fejka, Raymond A. Farkas, Kunihiko Yokoyama et al.
      Pages 215-227
      PDF
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About this book

The advent of hybridoma technology leading to the successful produc­ tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.
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Keywords

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Editors and Affiliations

  • Brookhaven National Laboratory, Upton, USA

    Suresh C. Srivastava

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Bibliographic Information

  • Book Title: Radiolabeled Monoclonal Antibodies for Imaging and Therapy

  • Editors: Suresh C. Srivastava

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5538-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1988

  • Softcover ISBN: 978-1-4684-5540-3Published: 18 January 2013

  • eBook ISBN: 978-1-4684-5538-0Published: 14 March 2013

  • Edition Number: 1

  • Number of Pages: XIV, 876

  • Topics: Immunology, Oncology

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Download book PDF

Buy it now

Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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