Experience with Iodine-123 Labeled Antibodies

  • Keith Britton
  • Marie Granowska
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)


In order to image the distribution of spread of metastases from a primary adenocarcinoma in a patient using radioimmunoscintigraphy, a combination of four factors is required: an antibody specific to the cancer in question; a radiolabel that is optimal for the imaging system and for the kinetics of antibody uptake; a method of labeling the antibody and quality control so that is is suitable for injection into the patient; and, a gamma camera imaging system that enables the distribution of the radiolabeled antibody to be visualized to the best advantage. Although it is evident that the major limitation of the current practice of radioimmunoscintigraphy is the inability to get sufficient numbers of a sufficiently specific antibody on to all the cancer cells that have spread from the primary site, this paper is concerned with the other three requirements: the radiolabel, the labeling method, and the imaging of its distribution, with particular reference to the use of iodine-123.


Ovarian Cancer Single Photon Emission Compute Tomography Gamma Camera Detection Figure Potassium Perchlorate 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Keith Britton
    • 1
    • 2
  • Marie Granowska
    • 1
    • 2
  1. 1.Department of Nuclear MedicineSt. Bartholomew’s Hospital and Medical CollegeLondon EC1UK
  2. 2.Imperial Cancer Research Fund UnitSt. Mark’s HospitalLondon EC2UK

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