Advertisement

The De Novo Generation of Germinal Centers is an Oligoclonal Process

  • Frans G. M. Kroese
  • Auk S. Wubbena
  • Hendrik G. Seijen
  • Paul Nieuwenhuis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

Germinal centers (GC) may develop in follicles of peripheral lymphoid organs as response to stimulation with T cell dependent antigens (for review see Nieuwenhuis and Opstelten, 1986). Essentially, GC are clusters of actively dividing B lymphoblastoid cells which are thought to give rise to memory-B cells. In addition to B cells, GC are composed of some T (helper) cells and a specific non-lymphoid cell, the follicular dendritic cell.

Keywords

Germinal Center Follicular Dendritic Cell Peripheral Lymphoid Organ Germinal Center Cell Leucocyte Common Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bazin, H., Cormant, F., and de Clerq, L., 1984, Rat monoclonal antibodies. II. A rapid and efficient method of purification from ascitic fluid or serum. J. Immunol. Meth. 71: 9.CrossRefGoogle Scholar
  2. Ford, W.L. and Hunt, S.V., 1973, The preparation and labeling of lymphocytes, in: “Handbook of Experimental Immunology”, D.M. Weir, ed., p. 231., Blackwell Scientific Publications, Oxford.Google Scholar
  3. Gastkemper, N.A., Wubbena, A.S., Gimbrere, F.J.H., de Graaf, A., and Nieuwenhuis, P., 1981, Germinal centres and the B cell system. V. Presence of germinal centre precursor cells among lymphocytes of the thoracic duct in the rat. Cell Tiss. Res. 219: 281.CrossRefGoogle Scholar
  4. Kampinga, J., Kroese, F.G.M., Pol, G.H., and Nieuwenhuis, P., 1987, HIS41: A new Mab detecting the RT7.2 but not the RT7.1 haplotype on lymphoid and myeloid cells. Adv. Exp. Med. Biol. (This volume).Google Scholar
  5. Klaus, G.G.B., Humphrey, J.H., Kunkl, A., and Dongworth, D.W., 1980, The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol. Rev. 53: 3.PubMedCrossRefGoogle Scholar
  6. Kroese, F.G.M., Wubbena, A.S., and Nieuwenhuis, P., 1986, Germinal centre formation and follicular antigen trapping in the spleen of lethally X-irradiated and reconstituted rats. Immunology 57: 99.PubMedGoogle Scholar
  7. Kroese, F.G.M., Wubbena, A.S., Seijen, H.G., and Nieuwenhuis., P., 1987a, Germinal centers develop oligoclonally. Eur. J. Immunol. 17: 1069.PubMedCrossRefGoogle Scholar
  8. Kroese, F.G.M., Wubbena, A.S., Opstelten, D., Deenen, G.J., Schwander, E.H., de Leij, L, Vos, H., Poppema, S., Volberda, J., and Nieuwenhuis, P., 1987b, B lymphocyte differentiation in the rat: production and characterization of monoclonal antibodies to B lineage associated antigens. Eur. J. Immunol. 17: 921.PubMedCrossRefGoogle Scholar
  9. Nieuwenhuis, P., and Opstelten, D., 1984, Functional anatomy of germinal centers. Am. J. Anat. 170: 421.PubMedCrossRefGoogle Scholar
  10. Springer, T.A., Bhattachara, A., Cardoza, J.T., and Sanches-Madrid., F., 1982, Monoclonal antibodies specific for rat lgG1, lgG2a, lgG2b subclasses, and kappa chain monocytic and allotypic determinants: reagents for use with rat monoclonal antibodies. Hybridoma 1: 257.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Frans G. M. Kroese
    • 1
  • Auk S. Wubbena
    • 1
  • Hendrik G. Seijen
    • 1
  • Paul Nieuwenhuis
    • 1
  1. 1.Department of HistologyUniversity of GroningenGroningenThe Netherlands

Personalised recommendations