The De Novo Generation of Germinal Centers is an Oligoclonal Process
Germinal centers (GC) may develop in follicles of peripheral lymphoid organs as response to stimulation with T cell dependent antigens (for review see Nieuwenhuis and Opstelten, 1986). Essentially, GC are clusters of actively dividing B lymphoblastoid cells which are thought to give rise to memory-B cells. In addition to B cells, GC are composed of some T (helper) cells and a specific non-lymphoid cell, the follicular dendritic cell.
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