Abstract
Insulin or insulin-like peptides have been reported to be present in, and may be synthesized by, organisms that do not have pancreatic beta cells (LeRoith, et al., 1980, 1981, 1983; Falkner, et al., 1975; Meneses and Oritz, 1975; Duve and Thorpe, 1979; Yuri, et al., 1980)., Similar reports have appeared claiming localization and possible synthesis of insulin in the extrapancreatic tissues of vertebrates (Hendricks, et al.,1983). Proposed extrapancreatic sites of insulin synthesis in mammalian species have including the brain (Havrankova, et al., 1978; Raizada, et al., 1979; Bernstein, et al., 1980; Rosenzweig, et al.,1980; Stevenson, 1982; Raizada, et al., 1983; Lee, et al., 1984; Clarke, et al., 1986), rodent and human pituitary (Hatfield, et al., 1981; Budd, et al., 1986; Budd, et al., 1987), rodent and human retina (Das et al., 1984, 1985), human retinoblastoma cells (Pansky, et al., 1986),, yolk sac (Muglia and Locker, 1984), human placenta (Liu, et al., 1985) and mouse seminal vesicle (Stahler et al., 1986, 1987).
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Bernstein, H.G., Dorn, A., Hahn, H-J., Kostmann, G., and Ziegler, M., 1980, Cellular localization of insulin-like immunoreactivity in the central nervous system of spiny mice, C56B16J and C57B1KsJ mice. Acta Histochem. Cytochem. 13: 623–628
Boyd, F.T., Jr., Clarke, D.W., Muther, T.F. and Raizada, M.K., 1985, Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain. J. Biol. Chem. 15: 15880–15884
Brahic, M. and Haase, A.T., 1978, Detection of viral sequences of low reiteration frequency by in situ hybridization. Proc. Natl. Acad. Sci. USA 75: 6125–6129
Budd, G.C., Pansky, B., Cordell, B., 1986, Detection of insulin synthesis in mammalian anterior pituitary cells by immunocytochemistry and demonstration of insulin-related transcripts by in-situ RNA-DNA hybridization. J. of Histochem. Cytochem. 34: 673–678
Budd, G.C., Pansky, B. and Budd, N.J., 1987, Insulin or insulin-like peptides in the human pituitary. Ann. Clin. Lab. Sci.
Clarke, D.W., Mudd, L., Boyd, F.T., Jr., Fields, M. and Raizada, M.K., 1986, Insulin is released from rat brain neuronal cells in culture. J. Neurochem. 47: 831–836
Das, A., Pansky, B., Budd, G. C. and Kollarits, C.R., 1984, Immunocytochemistry of mouse and human retina with antisera to insulin and S-100 protein. Curr. Eye Res. 3: 1397–1403
Das, A., Budd, G.C., Pansky, B., Cordell, B., and Kollarits, C.R., 1985, retinal glial cells. Invest. Ophthalmol. Vis. Insulin-specific mRNA in rat Sci., Suppl. 26(3):337
Dorn A, Bernstein HG, Hahn HJ, Ziegler M, and Rummelfanger H., 1981, Insulin immunocytochemistry of the rodent’s CNS: apparent species differences but good correlation with radioimmunological data. Histochemistry 71: 609
Duve, H., Thorpe, A., 1979, Immunofluorescent localization of insulin-like material in the medial secretory cells of the blowfly Calliphora vomitoria. Cell Tissue Res. 200: 187–191
Falkner, S., Emdin, S., Havu, N., Lundgren, G., Marques, M., Ostberg, Y., Steiner, D.F., and Thomas, N.W., 1975, Insulin in invertebrates and cyclostomes. Am Zool. 13: 625–638
Gall, J.G., and Pardue, M.L., 1971, Nucleic acid hybridization in cytological preparations. In: “Methods in Enzymology,” Vol. XXI. L. Grossman and K. Moldave, eds., Academic Press, New York.
Gee, C.E., Chen, C-L., Roberts, J.L., Thompson, R., Watson, S.J., 1983, Identification of the proopiomelanocortin neurones in rat hypothalamus by in situ cDNA-mRNA hybridization. Nature 306: 374
Hatfield, J.S., Pansky, B., Waller, H. J. and Budd, G.C., 1981, Insulin-like immunoreactivity in cells of the mouse anterior pituitary. Micron 12: 205–206
Hatfield, J.S., Pansky, B., Waller, H. J. and Budd, G. C., 1981, Immunoperoxidase-labeled insulin antibody localization in mouse hypothalamus and pituitary. J. Cell Biol. 83: 138a
Havrankova J., Schmechel D., Roth J., and Brownstein M., 1978, Identification of insulin in the rat brain. Proc Natl Acad Sci USA 75: 5737.
Hendricks S.A., Roth J., Rishi S., and Becker, K.L., 1983, Insulin in the nervous system. In “Brain Peptides,” Krieger D.T., Martin J.B., and Brownstein J.J., editors. New York, John Wiley and Sons.
Karten H.J., and Brecha N., 1983, Localization of neuroactive substances in the vertebrate retina: evidence for lamination in the inner plexiform layer. Vision Res. 23: 1197.
Kuwabara T., and Cogan D.G., 1961, Retinal glycogen. Arch Ophthalmol 66: 680.
LeRoith D., Shiloach J., Roth J., and Lesniak, M.A., 1980, Evolutionary origins of vertebrate hormones: substances similar to insulins are native to unicellular enkaryotes. Proc Natl Acad Sci USA 77: 6184.
LeRoith D., Shiloach J., Roth J., and Lesniak M.A., 1981, Insulin or a closely related molecule is native to Escherichia coli. J. Biol. Chem. 256: 6533.
LeRoith D., Hendricks S.A., Lesniak M.A., Rishi S., Becker K.L., Havrankova J., Rosenzweig, J.L., Brownstein M.J., Roth J., 1983, Insulin in brain and other extrapancreatic tissues of vertebrates and nonvertebrates. In “Advances in Metabolic Diseases,” Szabo A.J., Levine R., and Luft R., eds., Academic Press, New York, Vol. 10.
Lee, C.H., Lin, B.C., Costa, E., and Chuang, D.M., 1984, Detection of mRNA species in the brain and other tissues of rat which hybridize with the pro-insulin gene. Fed. Proc. 43: 2219A
Liu, K-S., Wang, C-Y., Mills, N., Gyves, M., and Ilan, J., 1985, Insulin genes expressed in human placenta from normal and diabetic pregnancies. Proc. Natl. Acad. Sci. USA 82: 3868–3870
Meneses, P., and Oritz, M.A., 1975, A protein extract from Drosophila melanogaster with insulin-like activity. Comp. Biochem. Physiol. 51A: 483–485
Muglia, L., and Locker, J., 1984, Extrapancreatic insulin gene expression in the fetal rat. Proc. Natl. Acad. Sci. USA 81: 3635–3639
Pansky, B., Das, A., Budd, G.C., and Reid, T.W., 1986, Insulin-like immunoreactivity in hunian retinoblastoma Y79 cell line. Neuroscience Lett. 68: 187–191
Pansky B. and Hatfield J.S., 1978, Cerebral localization of insulin by immunofluorescence. Am. J. Anat. 153: 459
Puro D.G. and Agardh E., 1984, Insulin-mediated regulation of neuronal maturation. Science 225: 1170.
Raizada, M., 1983, Localization of insulin-like immunoreactivity in neurons from primary cultures of rat brain. Expl. Cell Res. 143: 351–357
Raizada, M.K., Weyhenmeyer, J.A., Fellows, R.E., 1979, Cells cultured from rat brain synthesize immunoreactive insulin. In Vitro 15: 185A
Raizada, M.K., 1983, Localization of insulin-like immunoreactivity in the neurons from primary cultures of rat brain. Exp. Cell Res. 143: 351.
Rhoads, D.E., DiRocco, R.J., Osburn, L.D., Peterson, N.A., and Raghupathy, E., 1984, Stimulation of synaptosomal uptake of neurotransmitter amino acids by insulin: possible role of insulin as a neuromodulator. Biochem. Biophys. Res. Comm. 119: 1198.
Rosenzweig, J.L., Havrankova, J., Lesniak, M.A., Brownstein, M., and Roth, J., 1980, Insulin is ubiquitous in exrapancreatic tissues of rats and humans. Proc. Natl. Acad. Sci. USA 77: 572–576
Stahler, M.S., Pansky, B., and Budd, G.C., 1986, Immuno-cytochemical localization of insulin-like immunoreactivity in mouse seminal vesicle. Biol. of Reprod. 35: 1075–1080
Stahler, M.S., Budd, G.C., and Pansky, B., 1987, Evidence for insulin synthesis in normal mouse seminal vesicle based on in situ RNA-DNA hybridization. Biol. Reprod. (In Press)
Stevenson, R.W., 1983, Further evidence for non-pancreatic insulin immunoreactivity in guinea pig brain. Horm. Metabol. Res. 15: 526–529
Stoner, G.D., You, M., Skouv, J., Budd, G.C., Pansky, B. and Wang, Y., 1987, Detection of oncogene mRNA sequences by in situ hybridization. Ann. Clin. Lab. Sci.
Varandani, P.T., Organisciak, D.T., and Nafz, M.A., 1982, The occurrence of glutathione-insulin transhydrogenase in the retina. Invest. Ophthalmol. Vis. Sci. 22: 715.
Yuri, R., Fujita, T., and Ito, A., 1980, Insulin-, glucagon-, gastrin-, pancreatic polypeptide-like immunoreactive neurons in the brain of the silkworm, Bombyx mori. Biomed. Res. 1: 42–46
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Budd, G.C., Pansky, B. (1987). Synthesis of Insulin or a Similar Peptide in the Pituitary Gland and in Retinal Muller Cells. In: Raizada, M.K., Phillips, M.I., LeRoith, D. (eds) Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5380-5_11
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DOI: https://doi.org/10.1007/978-1-4684-5380-5_11
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