Abstract
Diets low in total fats are widely recommended for the general public for the purpose of prevention of coronary heart disease (CHD). These diets lower the plasma cholesterol and low-density lipoproteins, and they are consumed in many countries where the prevalence of CHD is low. However, low-fat diets have not been widely accepted in the United States and other countries where rates of CHD are high. Although there has been a moderate reduction in fat intake among Americans, this change has not been sufficient to produce a major reduction in plasma cholesterol. For this reason, an alternate approach to lowering the plasma cholesterol by diet is needed.
One approach is to use a diet high in polyunsaturated fatty acids. When polyunsaturates are substituted for saturates in the diet, the result is a fall in cholesterol levels. For this reason, polyunsaturates have been widely advocated. However, polyunsaturates have potential drawbacks. No large populations have ever consumed large amounts of polyunsaturates to prove their safety. Furthermore, these fatty acids have adverse effects in laboratory animals; they suppress the immune system and promote the development of experimental cancer. Thus, many investigators oppose the addition of large amounts of polyunsaturates to the American diet.
A third approach to a cholesterol-lowering diet is to use monounsaturated fatty acids. Monoun-saturates have been consumed in the Mediterranean region for many years, where rates of coronary heart disease and cancers are relatively low. We have carried out metabolic ward studies and have shown that monounsaturates are as effective as both polyunsaturated fatty acids and carbohydrates for lowering plasma total cholesterol and low-density lipoproteins. However, monounsaturates do not lower high-density lipoproteins as do polyunsaturates and carbohydrates. Therefore, monounsaturates appear to be at least as effective as the other two constituents for cholesterol lowering.
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References
Grundy, S. M., 1982, Hypertriglyceridemias: Mechanisms, clinical significance, and treatment, Med. Clin. North Am. 66:519–535.
Grundy, S. M., 1986, Comparison of monounsaturated fatty acids and carbohydrates for plasma cholesterol lowering, N. Engl. J. Med. 314:745–748.
Grundy, S. M. Bilheimer, D., Blackburn, H., Brown, W. V., Kwiterovich, P. O., Jr., Mattson, F., Schonfeld, G., and Weidman, W. H., 1982, Rationale of the diet–heart statement of the American Heart Association. Report of Nutrition Committee, Circulation 65:839A–854A.
Hegsted, D. M., McGandy, R. B., Myers, M. L., and Stare, F. J., 1965, Quantitative effects of dietary fat on serum cholesterol in man, Am. J. Clin. Nutr. 17:281–295.
Kannell, W. B., Castelli, W. P., and Gordon, T., 1979, Cholesterol in the prediction of atherosclerotic disease, Am. Intern. Med. 90:85–91.
Kesaniemi, Y. A., and Grundy, S. M., 1983, Increased low density lipoproduction associated with obesity, Arteriosclerosis 3:170–177.
Kesteloot, H., Huang, D. X., Yang, X. S., Claes, J., Rosseneu, M., Geboers, J., and Joossens, J. V., 1985, Serum lipids in the Peoples Republic of China. Comparison of Western and Eastern Populations, Arteriosclerosis 5:427–433.
Keys, A. (ed.), 1970, Coronary heart disease in seven countries, Circulation 41 (Suppl.):I–l–211.
Keys, A., Anderson, J. T., and Grande, F., 1965, Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet, Metabolism 14:776–787.
Mattson, F. H., and Grundy, S. M., 1985, Comparison of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man, J. Lipid Res. 26.194–202.
National Diet–Heart Study (The), 1968, Final report, Circulation 37–38 (Suppl.):I–l–428.
Neaton, J. D., Kuller, L. H., Wentworth, D., and Borhani, N. O., 1984, Total and cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for five years, Am. Heart J. 108:759–769.
Pooling Project Research Group (The), 1978, Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events; final report of the pooling project, J. Chron. Dis. 31:201–306.
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© 1987 Plenum Press, New York
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Grundy, S.M. (1987). Diet and Coronary Heart Disease. In: Gallo, L.L. (eds) Cardiovascular Disease. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5296-9_59
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DOI: https://doi.org/10.1007/978-1-4684-5296-9_59
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