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Cardiovascular Disease

Molecular and Cellular Mechanisms, Prevention, and Treatment

  • Linda L. Gallo

Table of contents

  1. Front Matter
    Pages i-xv
  2. Lipoprotein Metabolism

    1. Front Matter
      Pages 1-1
    2. James Shepherd, Christopher J. Packard
      Pages 3-8
    3. Anna M. Kessling, Philippa J. Talmud, Nazzarena Barni, Peter Carlsson, Caterina Darnfors, Gunnar Bjursell et al.
      Pages 15-20
    4. S. W. Law, J. C. Monge, K. J. Lackner, S. Grant, K. Higuchi, A. V. Hospattanker et al.
      Pages 21-32
    5. S. S. Fojo, L. Taam, S. W. Law, R. Ronan, C. Bishop, M. Meng et al.
      Pages 33-50
    6. Elizabeth A. Laposata, Jerome F. Strauss III, Henry M. Laboda, Jane M. Glick
      Pages 51-59
  3. Lipoprotein Metabolism

    1. Front Matter
      Pages 77-77
    2. Michael S. Brown, Joseph L. Goldstein
      Pages 87-91
    3. Richard E. Gregg, Loren A. Zech, Carlo Gabelli, Jeffrey M. Hoeg, H. Bryan Brewer Jr.
      Pages 93-102
    4. Ira Tabas, George C. Boykow, David A. Weiland, Alan R. Tall
      Pages 121-132
    5. O. Stein, Y. Stein
      Pages 139-144
    6. Gerhard A. Coetzee, Denver T. Hendricks, Wieland Gevers, Deneys R. van der Westhuyzen
      Pages 145-150
    7. Charles J. Glueck, Ingrid Borecki, D. C. Rao, Peter Laskarzewski
      Pages 157-163
    8. Alan Chait, R. Alan Failor, John J. Albers, David Foster, John D. Brunzell
      Pages 165-169
  4. Vessel Wall Biology

    1. Front Matter
      Pages 171-171
    2. Pietro M. Gullino
      Pages 173-176
    3. Roberto F. Nicosia, Joseph A. Madri
      Pages 185-192
    4. Hanoch Alpern-Elran, Gayle Hoover, Norman Kalant, Steven Brem
      Pages 193-198
    5. Morris J. Karnovsky, John J. Castellot Jr., Thomas C. Wright
      Pages 199-209
    6. Jordan S. Pober
      Pages 211-217
    7. Maurice Nachtigal, Phillip Greenspan, Stanley D. Fowler, Eugene P. Mayer
      Pages 227-234
    8. Arthur Penn, Seymour J. Garte, Lisa Warren
      Pages 235-247
  5. Vessel Wall Biology

    1. Front Matter
      Pages 249-249
    2. Ralph L. Nachman, Roy L. Silverstein
      Pages 251-253
    3. J. P. Caen, Y. Legrand, A. Karniguian, D. Leger, C. Soria, J. Soria et al.
      Pages 277-281
    4. David J. Loskutoff, Raymond R. Schleef, Michael Sawdey
      Pages 283-289
    5. Daniel S. Rush, Morris D. Kerstein, John A. Bellan, Suzanne M. Knoop, Philip R. Mayeux, Albert L. Hyman et al.
      Pages 291-297
    6. John W. Karanian, Norman Salem Jr.
      Pages 299-321
    7. Linda L. Slakey, Ellen L. Gordon
      Pages 323-328
  6. Atherosclerosis

    1. Front Matter
      Pages 335-335
    2. Robert W. Wissler, Dragoslava Vesselinovitch
      Pages 337-357
    3. Jason C. H. Shih, Roman Pyrzak
      Pages 359-364
    4. Motoomi Nakamura, Hitonobu Tomoike, Kensuke Egashira
      Pages 365-368
    5. Thomas B. Clarkson, Michael R. Adams, Jay R. Kaplan, Donald R. Koritnik
      Pages 373-379
    6. Michael R. Adams, Jay R. Kaplan, Thomas B. Clarkson, Donald R. Koritnik
      Pages 381-387

About this book

Introduction

The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con­ tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li­ poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab­ olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.

Keywords

Lipid atherosclerosis cardiovascular heart disease lipoprotein metabolism mutation protein proteins receptor synthesis tissue vascular disease

Editors and affiliations

  • Linda L. Gallo
    • 1
  1. 1.The George Washington University Medical CenterUSA

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