Cardiovascular Disease

Molecular and Cellular Mechanisms, Prevention, and Treatment

  • Linda L. Gallo

Table of contents

  1. Front Matter
    Pages i-xv
  2. Lipoprotein Metabolism

    1. Front Matter
      Pages 1-1
    2. James Shepherd, Christopher J. Packard
      Pages 3-8
    3. Anna M. Kessling, Philippa J. Talmud, Nazzarena Barni, Peter Carlsson, Caterina Darnfors, Gunnar Bjursell et al.
      Pages 15-20
    4. S. W. Law, J. C. Monge, K. J. Lackner, S. Grant, K. Higuchi, A. V. Hospattanker et al.
      Pages 21-32
    5. S. S. Fojo, L. Taam, S. W. Law, R. Ronan, C. Bishop, M. Meng et al.
      Pages 33-50
    6. Elizabeth A. Laposata, Jerome F. Strauss III, Henry M. Laboda, Jane M. Glick
      Pages 51-59
  3. Lipoprotein Metabolism

    1. Front Matter
      Pages 77-77
    2. Michael S. Brown, Joseph L. Goldstein
      Pages 87-91
    3. Richard E. Gregg, Loren A. Zech, Carlo Gabelli, Jeffrey M. Hoeg, H. Bryan Brewer Jr.
      Pages 93-102
    4. Ira Tabas, George C. Boykow, David A. Weiland, Alan R. Tall
      Pages 121-132
    5. O. Stein, Y. Stein
      Pages 139-144
    6. Gerhard A. Coetzee, Denver T. Hendricks, Wieland Gevers, Deneys R. van der Westhuyzen
      Pages 145-150

About this book

Introduction

The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con­ tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li­ poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab­ olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.

Keywords

Lipid atherosclerosis cardiovascular heart disease lipoprotein metabolism mutation protein proteins receptor synthesis tissue vascular disease

Editors and affiliations

  • Linda L. Gallo
    • 1
  1. 1.The George Washington University Medical CenterUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5296-9
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5298-3
  • Online ISBN 978-1-4684-5296-9
  • About this book