Evolution of Neuronal Ischemic Injury

  • Julio H. Garcia
  • K. A. Conger
Part of the NATO ASI Series book series (NSSA, volume 115)


A decrease of blood flow to the mammalian brain sufficiently severe to impair neuronal function constitutes the condition of ischemia. In several situations in human and animals it has been determined that neuronal activity, i.e. action potentials disappears, if cerebral blood flow (CBF) falls to a level below 12–15 m1/100g min (Sundt et al, 1981; Garcia, 1984). However, it has also been observed that this is reversible, as long as blood flow is reestablished within a short period of time. Different ischemic flow thresholds have been experimentally described for neurons. The flow threshold for release of K+ is clearly lower than the one resulting in complete electrical failure (Astrup, 1981).


Cerebral Blood Flow Cerebral Ischemia Brain Ischemia Ischemic Injury Serum Glucose Level 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Julio H. Garcia
    • 1
  • K. A. Conger
    • 1
  1. 1.Departments of Pathology and NeurologyUniversity of AlabamaBirminghamUSA

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