Mechanisms of Secondary Brain Damage

  • A. Baethmann
  • K. G. Go
  • A. Unterberg

Part of the NATO ASI Series book series (NSSA, volume 115)

Table of contents

  1. Front Matter
    Pages i-x
  2. Neuropathology of Primary and Secondary Brain Damage

    1. Head Injury

      1. J. Hume Adams, D. I. Graham, T. A. Gennarelli
        Pages 1-13
      2. Thomas A. Gennarelli, J. H. Adams, D. I. Graham
        Pages 15-28
      3. Raymond A. Clasen, P. Guariglia, R. J. Stein, S. Pandolfi, J. J. Lobick
        Pages 29-45
    2. Cerebral Ischemia

  3. Pathophysiological and Biochemical Mechanisms

    1. Cerebral Edema

    2. Cerebral Ischemia

  4. Clinical Aspects and Treatment

    1. Head Injury

    2. Cerebral Ischemia

      1. Petter A. Steen, S. E. Gisvold, L. A. Newberg, W. L. Lanier, B. W. Scheithauer, J. D. Michenfelder
        Pages 377-380
      2. Cesare Fieschi, N. Battistini, S. Passero, M. Rasura
        Pages 381-386
  5. Back Matter
    Pages 387-406

About this book


A distinction between primary and secondary brain damage of vari­ ous origin, particularly in acute lesions, such as head injury and ische­ mia is not entirely new. The concept is of practical significance, be­ cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam­ age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro­ vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho­ logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon­ cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.


Pet Steroid brain circulation development fields influence kinetics structure

Editors and affiliations

  • A. Baethmann
    • 1
  • K. G. Go
    • 2
  • A. Unterberg
    • 1
  1. 1.University of MunichMunichWest Germany
  2. 2.University of GroningenGroningenHolland

Bibliographic information