Relevance of Primary and Secondary Brain Damage for Outcome of Head Injury
The outcome of head injury in the human depends upon the interaction of pre-injury factors, the nature of the injury to the skull and brain and secondary factors that lead to further brain dysfunction and damage (Miller and Becker, 1982). The important pre-injury factors are age, the psychosocial status of the patient and state of health prior to injury, in particular previous brain injury, hydrocephalus or stroke.
KeywordsHead Injury Intracranial Hypertension Cerebral Perfusion Pressure Brain Damage Severe Head Injury
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- Adams JH, The neuropathology of head injuries, in: “Handbook of clinical neurology”, Vol 23, Vinken PJ, Bruyn GW, eds., Elsevier-North Holland Publ. Co., Amsterdam (1975).Google Scholar
- Becker DP, Miller JD, Young HF, Selhorst JB, Kishore PRS, Greenberg RP, Rosner MJ, Ward DJ, Diagnosis and treatment of head injury, in: “Neurological surgery”, Vol 4, Youmans J, ed., Saunders, Philadelphia (1982).Google Scholar
- Graham DI, Adams JH, Ischaemic brain damage in fatal head injuries, Lancet 1: 275 (1971).Google Scholar
- Miller JD, Becker DP, General principles and pathophysiology of head injury, in: “Neurological surgery”, Vol 4, Youmans J, ed., Saunders, Philadelphia (1982).Google Scholar
- Miller JD, Becker DP, Secondary insults to the injured brain, J Roy Coll Surg Edin 27: 292 (1982).Google Scholar
- Miller JD, Butterworth JF, Gudeman SK, Faulkner JE, Choi SC, Selhorst JB, Harbison JW, Lutz H, Young HF, Becker DP, Further experience in the management of severe head injury, J Neuro-surg 54: 289 (1981).Google Scholar
- Wei EP, Dietrich WD, Povlishock JT, Kontos HA, Functional, morphological and metabolic abnormalities of the cerebral microcirculation after concussive trauma in cats, Circ Res 46: 37 (1980).Google Scholar