Proopiomelanocortin-Derived Peptides and Their Receptors in the Immune System
It has been known for many years that stressful situations can be a contributing factor in the development of a variety of bacterial, viral, and neoplastic diseases (Riley, 1981; Stein, 1985). Specifically, decreased immunocompetence seems to account for the increased susceptibility of stressed hosts for these disease states. An increasing interest in the biochemical basis for this stress-induced immune suppression has resulted in the emergence of a new discipline (Holden, 1980). This field has been referred to as psychoimmunology, neuroimmunoendocrinology, neu-roimmunomodulation, and behavioral medicine. Regardless of the title given to this new field, the question being addressed is the same: How are the nervous, endocrine, and immune systems interrelated?
KeywordsVasoactive Intestinal Peptide Vasoactive Intestinal Polypeptide Opiate Receptor Adrenal Cell Mononuclear Leukocyte
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