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The Varied Localization and Functional Significance of Kallikrein-Like Enzymes in Salivary Glands, Pancreas, Colon, Sex Glands and Spermatozoa, Including Evidence for the Presence of Nerve Growth Factor (NGF) in Bull Sperm Acrosome

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Kinins IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 198A))

Abstract

There has been considerable recent progress in the cellular and subcellular localization of kallikreins (or kininogenases) and related serine proteases.1–8 In this report, we review briefly our localization studies - some published and some new observations. These include studies on the salivary glands and colon of various mammals, the sex glands of the guinea pig, and the spermatozoa of boar, bull and man. In addition, we report our observations on the presence of Nerve Growth Factor (NGF) in bull sperm.

This communication duplicates in part, and extend our publication in Kinis III, Advances in Experimental Medicine and Biology, Vol. 156A, pp. 377–386, eds. H. Fritz et al., Plenum Press, New York, 1983. Due to printer’s error, the legends to the figures were incorrect in the previous publication. Some of these figures are, therefore, correctly republished here.

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References

  1. T. B. Ørstavik, K. Nustad, and P. Brandtzaeg, Origin of kallikrein in rat and human exocrine glands and kidney, Clin. Sci., 57: 2395, (1979).

    Google Scholar 

  2. T. B. Ørstavik, K. Nustad, and P. Brandtzaeg, Localization of blandular kallikreins in rat and man, in: Enzymatic Release of Vasoactive Peptides ed. by F. Gross and G. Vogel, Raven Press, New York, pp. 137–149, (1980).

    Google Scholar 

  3. M. Schachter, Kallikrein localization and its significance, in: Enzymatic Release of Vasoactive Peptides ed. by F. Gross and G. Vogel, Raven Press, New York, pp. 151–160, (1980a).

    Google Scholar 

  4. M. Schachter, Kallikreins (kininogenases) - a group of serine pro teases with bioregulatory actions, Pharmacol. Rev., 31: 1, (1980b).

    Google Scholar 

  5. M. Schachter, B. Maranda, and C. Moriwaki, Localization of kallikrein in the coagulating and submandibular glands of the guinea-pig, J. Histochem. Cytochem., 26: 318, (1978).

    Article  PubMed  CAS  Google Scholar 

  6. M. Schachter, M. W. Peret, C. Moriwaki, and J. A. A. Rodrigues, Localization of kallikrein in submandibular bland of cat, guinea- pig, dog and man by the immunoperoxidase method, J. Histochem. Cytochem., 28: 1295, (1980).

    Article  PubMed  CAS  Google Scholar 

  7. M. Schachter, M. W. Peret, A. G. Billing, and G. D. Wheeler, Immunolocalization of the protease kallikrein in the colon, J. Histochem. Cytochem., 31: 1255, (1983a).

    Article  PubMed  CAS  Google Scholar 

  8. M. Schachter, G. D. Wheeler, R. W. Matthews, M. W. Peret, and C. Moriwaki, Ultrastructural immunolocalization of kallikrein in apical granules of striated duct cells of cat submandibular gland, J. Histochem. Cytochem., 31: 345, (1983b).

    Article  PubMed  CAS  Google Scholar 

  9. B. Maranda, J. A. A. Rodrigues, M. Schachter, T. K. Shnitka, and J. Weinberg, Studies on kallikrein in the duct systems of the salivary glands of the cat, J. Physiol., 276: 321, (1978).

    PubMed  CAS  Google Scholar 

  10. S. Barton, E. J. Sanders, M. Schachter, and M. Uddin, Autonomic nerve stimulation, kallikrein content and acinar cell granules of the cat’s submandibular gland, J. Physiol., 251: 363, (1975).

    PubMed  CAS  Google Scholar 

  11. M. Schachter, S. Barton, M. Uddin, E. Karpinski, and E. J. Sanders, Effects of nerve stimulation, denervation, and duct ligation, on kallikrein content and duct cell granules of the cat’s submandibular gland, Experientia, 33: 746, (1977).

    Article  PubMed  CAS  Google Scholar 

  12. S. Beilenson, M. Schachter, and H. Smaje, Secretion of kallikrein and its role in vasodilatation in the submaxillary gland, J. Physiol., 199: 303, (1968).

    PubMed  CAS  Google Scholar 

  13. E. K. Frey, H. Kraut, and E. Werle, Das Kallikrein-Kinin System and Seine Inhibitoren, Enke, Stuttgart, (1968).

    Google Scholar 

  14. K. Yasuda and A. H. Coons, Localization by immunofluorescence of amylase, trypsinogen and chymotrypsinogen in the acinar cells of the pig pancreas, J. Histochem. Cytochem., 14: 303, (1965).

    Article  Google Scholar 

  15. T. Dietl, J. Kruck, and H. Fritz, Localization of kallikrein in procine pancreas and submandibular gland as revealed by the direct immunofluorescence technique, Hoppe Seylerfs Z. Physiol. Chem., 359: 499, (1978).

    CAS  Google Scholar 

  16. G. S. Pinkus, M. Maier, D. C, Seldin, O. Ole-Moiyoi, K. F. Austen, and J. C. Spragg, Immunohistochemical localization of glandular kallikrein in the endocrine and exocrine human pancreas, J. Histochem. Cytochem., 31: 1279, (1983).

    Article  PubMed  CAS  Google Scholar 

  17. A. Dorn, G, Koch, H. Zuhlke, B. Arlt, D. Lorenz, and M. Ziegler, The immunochemical investigation of trypsin and trypsin-like activity in the small intestine, pancreas and isolated Langerhans islets, Acta Histochem., 63: 26, (1978).

    CAS  Google Scholar 

  18. R. G. Woodbury, G. M. Gruzenski, and D. Lagunoff, Immunofluorescent localization of a serine protease in rat small intestine, Proc. Natl. Acad. Sci,, U.S.A., 75: 2785, (1978).

    Article  PubMed  CAS  Google Scholar 

  19. J. R. Garrett, J. D. Harrison, A. Kidd, K. Kyriacou, and R. E. Smith, Kallikrein-like activity in human salivary glands and colon, including mast cells, J. Physiol., 334: 78P, (1982a).

    Google Scholar 

  20. J, R. Garrett, R. E. Smith, A. Kidd, K. Kyriacou, and R. J. Grabske, Kallikrein-like activity in salivary glands using a new tripeptide substrate, including preliminary secretory studies and observations on mast cells, Histochem. J., 14: 967, (1982b).

    Article  PubMed  CAS  Google Scholar 

  21. J. R. Garrett, A. Kidd, K. Kyriacou, and R. E. Smith, New observations on the localization of kallikrein-like activity in human salivary parenchymal and mast cells by enzyme histochemistry, Histochem. J., 16: 789, (1984).

    Article  PubMed  CAS  Google Scholar 

  22. K. D. Bhoola, R, May Hay Yi, J. Morley, and M. Schachter, Kinin- releasing enzyme in the accessory sex glands of the guinea-pig, J. Physiol., 159: 34 – 35P, (1961).

    Google Scholar 

  23. K. D. Bhoola, R. May May Yi, J. Morley, and M. Schachter, Release of kinin by an enzyme in the accessory sex glands of the guinea- pig, J. Physiol., 162: 269, (1962).

    Google Scholar 

  24. M. Schachter, Kinins of various origins, Ann. N. Y. Acad. Sci., 104: 108, (1963).

    Article  PubMed  CAS  Google Scholar 

  25. C. Moriwaki and M. Schachter, Kininogenase of the guinea-pig’s coagulating gland and the release of bradykinin, J. Physiol., 219: 341, (1971).

    PubMed  CAS  Google Scholar 

  26. K. Kizuki, C. Moriwaki, and H. Moriya, Kinin-converting factor in the dog pseudoglobulin fraction from heated plasma and kinin liberation from dog kininogen by guinea-pig coagulating gland kallikrein (CGK), Chem. Pharm. Bull. (Japan), 28: 42, (1980).

    Article  CAS  Google Scholar 

  27. S. Barton, J. Wimalasema, and M. Schachter, Subcellular location of the kininogenase in the coagulating gland of the guinea-pig, Biochem. Pharmacol., 22: 1121, (1973).

    Article  CAS  Google Scholar 

  28. G. P. Harper, Y. A. Barde, G. Burnstock, J. R. Carstairs, M. E. Dennison, K. Suda, and C. A. Vernon, Guinea-pig prostate is a rich source of nerve growth factor, Nature (London), 279: 160, (1979).

    Article  CAS  Google Scholar 

  29. H. Fritz, W. D. Schleuming, H. Schiessler, W. B. Schill, V. Wendt, and G. Winkler, Boar, bull and human sperm acrosin - isolation, properties and biological aspects, in: Proteases and Biological Control, ed. by E. Reich, D. B. Rifkin and E. Shaw, Cold Spring Harbor Laboratory, pp. 715–735, (1975).

    Google Scholar 

  30. L. J. D. Zaneveld, K. L. Polakoski, and G. F. B. Schumachen, The proteolytic enzyme systems of mammalian genital tract secretions and spermatozoa, in: Proteases and Biological Control, ed. by E. Reich, D. B. Rifkin and E. Shaw, Cold Spring Harbor Laboratory, pp. 683–714, (1975).

    Google Scholar 

  31. W. Muller-Esterl, S. Kupfer, and H. Fritz, Purification and properties of boar acrosin, Hoppe Seyler’sZ. Physiol. Chem., 361: 1811, (1980).

    Article  CAS  Google Scholar 

  32. D. L. Garner, M. P. Easton, M. A. Munson, and M. A. Boane, Immunofluorescent localization of bovine acrosin, J. Exp. Zool., 191: 127, (1975).

    Article  PubMed  CAS  Google Scholar 

  33. D. B. Morton, The occurrence and function of proteolytic enzymes in the reproductive tract of mammals, in: Proteases in Mammalian Cells and Tissues, ed. by A. J. Barrett, North Holland Publ. Co., Amsterdam, pp. 445 – 500, (1977).

    Google Scholar 

  34. G. P. Harper and H. Thoenen, The distribution of nerve growth factor in the male sex organs, J. Neuroehem., 34: 893, (1980).

    Article  CAS  Google Scholar 

  35. R. M. Stroud, A family of protein-cutting proteins, Sci. Amer., 231: 74, (1974).

    Article  PubMed  CAS  Google Scholar 

  36. F. Fiedler, W. Shret, C. Godec, C. Hirschauer, C. Kutzbach, G. Schmidt-Kastner, and H. Tschesche, The primary structure of pig pancreatic kallikrein B., in: Kininogenase 4, ed. by G. L. Haberland, J. W. Rogen, and T. Suzuki, Schattauer, Stuttgart- New York, pp. 7–14, (1977).

    Google Scholar 

  37. H. Fritz, F. Fiedler, T. Dietl, M. Warwas, E. Truscheit, G. Kolb, G. Mair, and H. Tschesche, On the relationship between porcine, pancreatic, submandibular, and urinary kallikreins, in: Kininogenases 4, ed. by G. L. Haberland, J. W. Rogen, and T. Suzuki, Schattauer, Stuttgart-New York, pp. 15–28, (1977).

    Google Scholar 

  38. H. Neurath and K. A. Walsh, The role of proteases in physiological regulation: an overview, Fed. Eur. Biochem. Soc. Symp., 47: 1, (1978).

    Google Scholar 

  39. F. Fiedler, Enzymology of glandular kallikreins, in: Bradykinin, kallidin and Kallikrein, ed. by E. G. Erdos, Springer-Verlag, Berlin, pp. 103–161, (1979).

    Google Scholar 

  40. M. A. Bothwell, W. H. Wilson, and E. M. Shooter, The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland, J. Biol. Chem., 254: 7287, (1979).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    M. Schachter, M. W. Peret, C. Moriwaki, G. D. Wheeler, R. W. Matthews, J. G. Mehta & T. Labedz

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  1. M. Schachter
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  2. M. W. Peret
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  3. C. Moriwaki
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  4. G. D. Wheeler
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  6. J. G. Mehta
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Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    Lowell M. Greenbaum Ph.D (President, IKC) (President, IKC)

  2. Medical University of South Carolina, Charleston, South Carolina, USA

    Harry S. Margolius Ph.D, M.D. (Vice President, IKC) (Vice President, IKC)

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© 1986 Plenum Press, New York

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Schachter, M. et al. (1986). The Varied Localization and Functional Significance of Kallikrein-Like Enzymes in Salivary Glands, Pancreas, Colon, Sex Glands and Spermatozoa, Including Evidence for the Presence of Nerve Growth Factor (NGF) in Bull Sperm Acrosome. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_1

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  • DOI: https://doi.org/10.1007/978-1-4684-5143-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5145-0

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