Abstract
Zona pellucida (ZP) is one of the potential target antigen for immunocontraception (1, 2). Conventional antibodies raised against ZP inhibit sperm-zona interaction in vitro (3–6) and block fertility in various species on active and passive immunization (7–10). Most studies have focussed on porcine ZP, in view of its immunological reactivity with human zonae. Moreover heterospecies antigen is also expected to be more immunogenic. Indeed immunization of rabbits with porcine zonae resulted in production of high antibody titres and block of fertility in contrast to rabbit zonae which were not as effective.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.G. Sacco, Immunocontraception: Consideration of the zona pellucida as a target antigen, in: “Obstetrics and Gynecology Annual”, R.M. Wynn, ed., 10: 1 (1981).
B.S. Dunbar, and D.J. Wolegemuth, Structure and function of the mammalian zona pellucida, a unique extracellular matrix, in: “Modern cell Biology”. B. Satir, ed., Alan R. Liss, Inc., New York, 3: 77 (1984).
C.A. Shivers, A.B. Dudkiewicz, L.E. Franklin, and E.N. Fussel, Inhibition of sperm-egg interaction by specific antibody, Science, 178: 1211 (1972).
A. Garavagno, J. Posada, C. Barros, and C.A. Shivers, Some characteristics of the zona pellucida antigen in the hamster, J. Exp. Zool. 189: 37 (1974).
F. Jilek, and A. Pavlok, Antibodies against mouse ovaries and their effect on fertilization in vitro and in vivo in mouse, J. Reprod. Fertil. 42: 377 (1975).
R. Yanagimachi, J. Winkelhake, and G.L. Nicolson, Immunological block to mammalian fertilization: Survival and organ distribution of immunoglobulin which inhibits fertilization in vivo, Proc. Natl. Acad. Sci, USA. 73: 2405 (1976).
R.J. Aitken, and D.W. Richardson, in: “Immunological aspects of reproduction and fertility control” J.P. Hearn, ed. MTP press, limited UK p. 173 (1980).
D.M. Wood, C. Lui, and B.S. Dunbar, Effect of alloimmunization and heteroimmunization with zonae pellucidae on fertility in rabbits, Biol. Reprod. 25: 439 (1981).
C.A. Mahi-Borwn, T.T.F. Huang, and R. Yanagimachi, Infertility in bitches induced by active immunization with porcine zona pellucida, J. Exp. Zool. 222: 89 (1982).
A.G. Sacco, M.G. Subramanian, E.C. Yurewicz, F.J. DeMayo, and W.R. Dekelow, Heteroimmunization of sequirrel monkeys (Saimiri schivreus) with purified porcine zona antigens (PPZA): Immune response and biologic activity of antigserum, Fertil. Steril, 39:350 (1983).
A.K. Bamezai, A. Bhattacharya, A.H. Band, Suman, G.P. Talwar, Diversity of antigenic determinants of porcine zona pellucida revealed by monoclonal antibodies, J. Biosci. 7:105 (1985).
C.A. Shivers, Immunological interference with fertilization in: “Karolinska Symposium on research methods in reproductive endocrinology”, 7th Symposium Immunological approaches to fertility control”, p. 223 (1974).
H.W. Denker, Role of proteinases in implantation, Prog. Reprod. Biol. 7: 28 (1980).
Z. Dickmann, Shedding of zona pellucida, Adv. Reprod. Physiol. 4: 187 (1969).
A. McLaren, A note on zona pellucida in mice, Adv. Reprod. Physiol. 4: 207 (1969).
A. McLaren, The fate of zona pellucida in mice, J. Embryol. Exp. Morph. 23:1 (1970).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Bamezai, A.K., Suman, Talwar, G.P. (1986). Characteristics of Anti-Zona Monoclonal Antibodies. In: Talwar, G.P. (eds) Immunological Approaches to Contraception and Promotion of Fertility. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5140-5_36
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5140-5_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5142-9
Online ISBN: 978-1-4684-5140-5
eBook Packages: Springer Book Archive