Abstract
In recent years it has been demonstrated that anti-sperm immunity is often associated with infertility in men and women, and a number of immunogenic sperm-specific antigens have been identified and characterized. It is now possible to mass produce these antigens by genetic engineering technology for use in contraceptive vaccine trials. However, knowledge of the complexities of the immune system and the manipulation of immune responses especially in the reproductive tissues lags considerably behind these more precise technological advances. Male and female reproductive tissues are naturally potential immunologic targets protected by immunologic barriers, immunosuppressive factors and possibly other immunoregulatory mechanisms. This area remains a largely unexplored research frontier and it is likely that considerable research on fundamental questions of reproductive immunology shall have to be performed before an effective contraceptive vaccine can be developed. In this chapter, I review certain classical immunologic considerations in the development of vaccines, focusing on immunological peculiarities of reproductive tissues and their antigens that require special consideration.
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References
Alexander, N.J., 1977, Summary of effects of vasectomy recorded in a number of species including man, in: “Immunological Influence on Human Fertility”, p. 242, B. Boettcher, ed., Acad. Press, New York.
Alexander, N.J. and Anderson, D.J., 1979, Vasectomy: Consequences of autoimmunity to sperm antigens, Fertil. Steril., 32: 253–260.
Allison, A.C., 1979, Mode of action of immunological adjuvants, J. Reticuloendothel. Soc., 26: 619–630.
Anderson, D.J., Alexander, N.J., Fulgham, D.L., Vandenbark, A.A. and Berger, D.R., 1982, Immunity to tumor-associated antigens in vasectomized men, J. Natl. Cancer Inst., 69: 551.
Anderson, D.J., Bach, D., Yunis, E.J. and DeWolf, W.C., 1982, Major Histocompatibility antigens are not expressed on human epididymal sperm, J. Immunol., 129: 452.
Anderson, D.J. and Tarter, T.H., 1982, Immunosuppressive effects of mouse seminal plasma components in vivo and in vitro, J. Immunol., 128: 535.
Anderson, D.J., Narayan, P. and DeWolf, W.C., 1984, Major Histocompatibility antigens are not detectable on post-meiotic human testicular germ cells, J. Immunol., 133: 1962.
Anderson, D.J., in press, Immunogenetic considerations in the development of contraceptive vaccines based on testicular sperm anitgens, in: “Male Contraception: Advances and Future Prospects”, G.I. Zatuchni, A. Goldsmith, J.M. Spieler and J.J. Sciarra, eds., Harper and Row Publishers, Philadelphia.
Bulmer, J. and Johnson, P.M., submitted.
Cunningham, A.J., 1980, Reliable vaccines using hybridoma products with defined idiotypes, in: “Strategies of Immune Regulation”, p. 497, E. Sercarz, A.J. Cunningham, eds., Acad. Press, New York.
Dorsman, B.G., Tumbh-Oeri, A.G. and Roberts, T.K., 1978, Detection of cell-mediated immunity to spermatozoa in mice and man by the leukocyte adherance-inhibition test, J. Reprod. Fertil., 53: 277.
Dym, M., 1973, The fine structure of the monkey (Macaca) Sertoli cell and its role in maintaining the blood-testis barrier, Anat. Rec, 175: 639.
Glater, G.B. and Anderson, D.J., 1985, Human seminal plasma inhibits the cytotoxic effect of natural killer (NK) cells, J. Androl., 6: 57.
Hamilton, D.W. 1975, Structure and function of the epithelium lining the ductuli efferentes, ductus epididymidis and ductus deferens in the rat, in: “Handbook of Physiology, Section 7, Endocrinology, Vol V, Male Reproductive System”, P. 259, R.O. Greep, Amer. Physiol. Soc., Washington D.C..
Hertenbach, U., Morgenstern, F. and Bennett, D., 1980, Induction of tolerance in vitro by autologous murine testicular cells, J. Exp. Med., 151: 1827.
Hertenbach, U. and Shearer, G.M., 1982, Germ cell-induced immune suppression in mice, effect of innoculation of syngeneic spermatozoa on cellmediated immune responses, J. Exp. Med., 155: 1719–1729.
Ishizaka, K., 1976, Cellular events in the IgE antibody response, Adv. Immunol., 23:1.
James, K., Harvey, J., Bradbury, A.W., Hargreave, T.B., Cullen, R.T. and Donaldson K., 1983, The effect of seminal plasma on macrophage function — a possible contributory role in sexually transmitted disease, AIDS Res., 1:45.
James, K. and Ssymaniec, S., 1985, Human seminal plasma is a potent inhibitor of natural killer cell activity in vitro, J. Reprod. Immunol., 8: 61.
Janeway, C.A., Bottomly, K., Babich, J., Conrad, P., Conzen, S., Jones, B., Kaye, J., Katz, M., McVay, L., Murphy, D.B. and Tite, J., 1984, Quantitative variation in Ia antigen expression plays a central role in immune regulation, Immunol. Today, 5: 99–105.
Kawamura, H., Rosenberg, S.A. and Berzofsky, J.A., 1985, Immunization with antigen and interleukin 2 in vivo overcomes Ir gene low responsiveness, J. Exp. Med., 162: 381–386.
Kille, J.W., Wheat, T.E., Mitchell, G. and Goldberg, E., 1978, Strain differences in the immune response of mice to homologous spermspecific lactate dehydrogenase (LDH-C4), Exp. Zool., 204: 259–266.
Lord, E.M., Sensabaugh, G.P. and Stites, D.P., 1977, Immunosuppressive activity of human seminal plasma I. inhibition of in vitro lymphocyte activation, J. Immunol., 118: 1704.
Madrigal, J.A., Yunis, E.J. and Anderson, D.J., in press, Genetic effects on sperm immunity: Quantitative and qualitative differences in sperm antibody responses in mice of different inbred strains and sexes, J. Reprod. Immunol.
Marsh, J.A., O’Hern, P. and Goldberg, E., 1981, The role of an x-linked gene in the regulation of secondary humoral response kinetics to sperm specific LDH-C4 antigen, J. Immunol., 126: 100.
McShane, P.M., Schiff, I. and Trentham, D., 1985, Cellular immunity to sperm in infertile women, J.A.M.A., 253: 3555.
Murdoch, A.J.M., Buckley, C.H. and Fox, H., 1982, Hormonal control of the secretory immune system of the human uterine cervix, J. Reprod. Immunol., 4: 23.
Nagarkatti, R.S. and Rao, S.S., 1976, Cell-mediated immunity to homologous spermatozoa following vasectomy in the human male, Clin. Exp. Immunol., 26: 239.
Reinisch, C.L., Gleiner, N.A. and Schlossman, S.F., 1976, Adjuvant Regulation of T cell function, J. Immunol., 116: 710–715.
Ritchie, A.W.S., Hargreave, T.B., James, K. and Chisholm, G.D., 1984, Intraepithelial lymphocytes in the normal epdidiymis. A mechanism for tolerance to sperm auto-antigens?, Brit. J. Urol., 56: 79–83.
Robb, R.J., 1984, Interleukin 2: the molecule and its function, Immunol. Today, 5: 203–209.
Roth, C., Somme, G. and Theze, J., 1983, Induction of an anti-GAT response in genetically responder and nonresponder mouse strains by monoclonal anti-idiotypic antibodies, Table Ronde Roussel U.C.L.A.F., 48: 465.
Sakaguchi, S., Fukuma, K., Kuribayashi, K. and Masuda, T., 1985, Organspecific autoimmune diseases induced in mice by elimination of T cell subset 1. Evidence for the active participation of T cell in natural self-tolerance, deficit of a T cell subset as a possible cause of autoimmune disease, J. Exp. Med., 161: 72–87.
Stites, D.P. and Erickson, R.P., 1975, Suppressive effect of seminal plasma on lymphocyte activation, Nature, 253: 727.
Taguchi, O. and Nishizuka, Y., 1981, Experimental autoimmune orchitis after neonatal thymectomy in the mouse, Clin. Exp. Immunol., 46: 425.
Tarter, T.H. and Alexander, N.J., 1982, Complement-inhibiting activity of seminal plasma, Am. J. Reprod. Immunol., 6: 28.
Tarter, T.H. and Isahakia, M., 1982, Inhibtion of complement-mediated hemolysis by aqueous extracts of monkey prostate and seminal vesicle, J. Androl., 3: 10.
Teuscher, C., Smith, S.M., Goldberg, E.H., Shearer, G.M. and Tung, K.S.K., in press, Experimental autoimmune orchitis in mice: genetic control of susceptibility and resistance to induction of orchitis.
Tung, K.S.K., Teuscher, C., Goldgerg, E.H. and Wild, G., 1981, Genetic control of antisperm autoantibody response in vasectomized quinea pigs, J. Immunol., 127: 835.
Tung, K.S.K., in press, Immunopathologic consideration of anti-fertility vaccine, in: “Male Contraception: Advances and Future Prospects”, G.I. Zatuchni, A. Goldsmith, J.M. Spieler and J.J. Sciarra, eds.
Weininger, R.B., Fisher, S., Rifkin, J. and Bedford, J.M., 1982, Experimental studies on the passage of specific IgG to the lumen of the rabbit epididymis, J. Reprod. Fertil., 66: 251–258.
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© 1986 Plenum Press, New York
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Anderson, D.J. (1986). Factors Affecting the Generation and Contraceptive Effectiveness of Immune Responses to Sperm. In: Talwar, G.P. (eds) Immunological Approaches to Contraception and Promotion of Fertility. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5140-5_25
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DOI: https://doi.org/10.1007/978-1-4684-5140-5_25
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